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The Role of Gastric Distention in Differentiating Recurrent Tumor from Physiologic Uptake in the Remnant Stomach on 18F-FDG PET

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dc.contributor.author유영훈-
dc.contributor.author윤미진-
dc.contributor.author이종두-
dc.date.accessioned2017-05-04T07:26:14Z-
dc.date.available2017-05-04T07:26:14Z-
dc.date.issued2005-
dc.identifier.issn0161-5505-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147286-
dc.description.abstractPhysiologic (18)F-FDG uptake in the stomach can often cause false-positive results and lowers the usefulness of (18)F-FDG PET in evaluating the remnant stomach. We assessed the role of gastric distension to see whether it is beneficial for the differentiation of recurrent tumors from physiologic (18)F-FDG uptake in the remnant stomach. METHODS: Thirty patients (22 men and 8 women; age range, 27-80 y; mean age, 58.3 y) with a history of subtotal gastrectomy for gastric cancer underwent (18)F-FDG PET for various clinical indications. After whole-body imaging, the patients were asked to drink water, and then spot imaging of the stomach was performed. (18)F-FDG uptake in the remnant stomach was considered positive for malignancy if it was persistently increased, whether focal or diffuse, after water ingestion. We used 2 standardized uptake value (SUV) criteria to differentiate benign from malignant uptake. First, a lesion was considered benign if its SUV was less than 2 on whole-body imaging. Second, for a lesion with an SUV of 2 or above, it was classified as benign if SUV decreased by more than 10% after water ingestion. RESULTS: Visual analysis of whole-body images produced 9 true-negative, 4 false-positive, 16 true-positive, and 1 false-negative results. Use of additional spot images produced 12 true-negative, 1 false-positive, 15 true-positive, and 2 false-negative results. When an SUV cutoff of 2 was applied for malignancy before water ingestion, all 17 patients with local recurrence were correctly identified, but 11 of the 13 patients without local recurrence were falsely considered to have a recurrent tumor in the remnant stomach. To reduce the false-positive results, we used the second SUV criterion after water ingestion. Use of that criterion produced 4 false-negative results although it correctly identified the 11 false-positive results as true negative. CONCLUSION: Gastric distension by having patients drink a glass of water seems to be a simple, cost-effective way of improving the diagnostic accuracy of (18)F-FDG PET in patients with suspected recurrence in the remnant stomach. Visual analysis with special attention to the configuration of (18)F-FDG activity after water ingestion seems to be more useful than the change in SUV in evaluating the remnant stomach.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherSociety of Nuclear Medicine-
dc.relation.isPartOfJOURNAL OF NUCLEAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/diagnosis*-
dc.subject.MESHAdenocarcinoma/diagnostic imaging-
dc.subject.MESHAdenocarcinoma/metabolism-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHFalse Positive Reactions-
dc.subject.MESHFemale-
dc.subject.MESHFluorine Radioisotopes/pharmacokinetics-
dc.subject.MESHFluorodeoxyglucose F18*/pharmacokinetics-
dc.subject.MESHGastrectomy-
dc.subject.MESHGastric Stump/diagnostic imaging*-
dc.subject.MESHGastric Stump/physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis*-
dc.subject.MESHNeoplasm Recurrence, Local/diagnostic imaging-
dc.subject.MESHNeoplasm Recurrence, Local/metabolism-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHRadiopharmaceuticals*/pharmacokinetics-
dc.subject.MESHStomach Neoplasms/diagnosis*-
dc.subject.MESHStomach Neoplasms/diagnostic imaging-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.subject.MESHWhole-Body Counting-
dc.titleThe Role of Gastric Distention in Differentiating Recurrent Tumor from Physiologic Uptake in the Remnant Stomach on 18F-FDG PET-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorHyun Seok Choi-
dc.contributor.googleauthorEunhye Yoo-
dc.contributor.googleauthorJung Kyun Bong-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorJong Doo Lee-
dc.identifier.doiOAK-2005-02359-
dc.contributor.localIdA02485-
dc.contributor.localIdA02550-
dc.contributor.localIdA03138-
dc.relation.journalcodeJ01644-
dc.identifier.eissn1535-5667-
dc.identifier.pmid15937305-
dc.subject.keyword15937305-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameLee, Jong Doo-
dc.citation.volume46-
dc.citation.number6-
dc.citation.startPage953-
dc.citation.endPage957-
dc.identifier.bibliographicCitationJOURNAL OF NUCLEAR MEDICINE, Vol.46(6) : 953-957, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid48459-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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