Cited 19 times in
Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis.
DC Field | Value | Language |
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dc.contributor.author | 김재우 | - |
dc.contributor.author | 김효정 | - |
dc.contributor.author | 유정환 | - |
dc.date.accessioned | 2017-02-27T08:21:30Z | - |
dc.date.available | 2017-02-27T08:21:30Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147160 | - |
dc.description.abstract | Glucocorticoids are associated with obesity, but the underlying mechanism by which they function remains poorly understood. Previously, we showed that small G protein Dexras1 is expressed by glucocorticoids and leads to adipocyte differentiation. In this study, we explored the mechanism by which Dexras1 mediates adipogenesis and show a link to the insulin-like growth factor-1 (IGF-1) signaling pathway. Without Dexras1, the activation of MAPK and subsequent phosphorylation of CCAAT/enhancer binding protein β (C/EBPβ) is abolished, thereby inhibiting mitotic clonal expansion and further adipocyte differentiation. Dexras1 translocates to the plasma membrane upon insulin or IGF-1 treatment, for which the unique C-terminal domain (amino acids 223-276) is essential. Dexras1-dependent MAPK activation is selectively involved in the IGF-1 signaling, because another Ras protein, H-ras localized to the plasma membrane independently of insulin treatment. Moreover, neither epidermal growth factor nor other cell types shows Dexras1-dependent MAPK activation, indicating the importance of Dexras1 in IGF-1 signaling in adipogenesis. Dexras1 interacts with Shc and Raf, indicating that Dexras1-induced activation of MAPK is largely dependent on the Shc-Grb2-Raf complex. These results suggest that Dexras1 is a critical mediator of the IGF-1 signal to activate MAPK, linking glucocorticoid signaling to IGF-1 signaling in adipogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 3T3-L1 Cells | - |
dc.subject.MESH | Adipocytes/metabolism* | - |
dc.subject.MESH | Adipogenesis* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Membrane/genetics | - |
dc.subject.MESH | Cell Membrane/metabolism* | - |
dc.subject.MESH | Glucocorticoids/genetics | - |
dc.subject.MESH | Glucocorticoids/metabolism* | - |
dc.subject.MESH | Insulin-Like Growth Factor I/genetics | - |
dc.subject.MESH | Insulin-Like Growth Factor I/metabolism* | - |
dc.subject.MESH | MAP Kinase Signaling System* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Protein Transport | - |
dc.subject.MESH | ras Proteins/genetics | - |
dc.subject.MESH | ras Proteins/metabolism* | - |
dc.title | Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis. | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology | - |
dc.contributor.googleauthor | Hyo Jung Kim | - |
dc.contributor.googleauthor | Jiyoung Y. Cha | - |
dc.contributor.googleauthor | Jo Woon Seok | - |
dc.contributor.googleauthor | Yoonjeong Choi | - |
dc.contributor.googleauthor | Bo Kyung Yoon | - |
dc.contributor.googleauthor | Hyeonjin Choi | - |
dc.contributor.googleauthor | Jung Hwan Yu | - |
dc.contributor.googleauthor | Su Jin Song | - |
dc.contributor.googleauthor | Ara Kim | - |
dc.contributor.googleauthor | Hyemin Lee | - |
dc.contributor.googleauthor | Daeun Kim | - |
dc.contributor.googleauthor | Ji Yoon Han | - |
dc.contributor.googleauthor | Jae-woo Kim | - |
dc.identifier.doi | 10.1038/srep28648 | - |
dc.contributor.localId | A00865 | - |
dc.contributor.localId | A01204 | - |
dc.contributor.localId | A04610 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 27345868 | - |
dc.contributor.alternativeName | Kim, Jae Woo | - |
dc.contributor.alternativeName | Kim, Hyo Jung | - |
dc.contributor.alternativeName | Yu, Jung Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Jae Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Jung | - |
dc.contributor.affiliatedAuthor | Yu, Jung Hwan | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 28648 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.6 : 28648, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47191 | - |
dc.type.rims | ART | - |
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