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MET Exon 14 Skipping in Non-Small Cell Lung Cancer.

DC FieldValueLanguage
dc.contributor.author심효섭-
dc.date.accessioned2017-02-27T08:14:59Z-
dc.date.available2017-02-27T08:14:59Z-
dc.date.issued2016-
dc.identifier.issn1083-7159-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147128-
dc.description.abstractBACKGROUND: Non-small cell lung cancers (NSCLCs) harboring specific genetic alterations can be highly sensitive to targeted therapies. MATERIALS AND METHODS: We performed a targeted rearrangement assay on 54 NSCLCs across all stages that were from patients who were never smokers and did not have driver mutations. Because MET exon 14 skipping was the most frequent alteration found, we surveyed the results for MET exon 14 skipping at Massachusetts General Hospital (MGH) since the inclusion of this alteration into our current molecular profiling panel. RESULTS: In a cohort of 54 never-smokers with lung cancers that were wild-type for known driver mutations, MET exon 14 skipping was the most frequently recurring alteration, occurring in 10 cancers (19%). Clinical testing at MGH via our next-generation sequencing (NGS) and NGS-rearrangement panels showed an additional 16 cases of MET exon 14 skipping, for an overall estimated frequency of 5.6%. A clinical case of a patient with MET exon 14 skipping treated with the MET inhibitor crizotinib is also described. CONCLUSION: MET exon 14 skipping is a targetable gene alteration found in NSCLC. Patients with these alterations may respond well to MET inhibition. IMPLICATIONS FOR PRACTICE: MET exon 14 skipping occurs with an approximately 5% frequency in NSCLC and is seen in both squamous and adenocarcinoma histology. Patients whose cancers have MET exon 14 skipping can respond well to MET inhibitors. Molecular testing for MET exon 14 skipping should be performed on all lung cancers because this is a targetable alteration.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent481~486-
dc.languageEnglish-
dc.publisherAlphaMed Press-
dc.relation.isPartOfOncologist-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/genetics*-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/pathology-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/therapy*-
dc.subject.MESHExons/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGene Rearrangement/genetics-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Targeted Therapy-
dc.subject.MESHNeoplasm Recurrence, Local/genetics*-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHProto-Oncogene Proteins c-met/antagonists & inhibitors-
dc.subject.MESHProto-Oncogene Proteins c-met/genetics*-
dc.subject.MESHSmoking/adverse effects-
dc.titleMET Exon 14 Skipping in Non-Small Cell Lung Cancer.-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorREBECCA S. HEIST-
dc.contributor.googleauthorHYO SUP SHIM-
dc.contributor.googleauthorSHALINI GINGIPALLY-
dc.contributor.googleauthorMARI MINO-KENUDSON-
dc.contributor.googleauthorLONG LE-
dc.contributor.googleauthorJUSTIN F. GAINOR-
dc.contributor.googleauthorZONGLI ZHENG-
dc.contributor.googleauthorMARTIN ARYEE-
dc.contributor.googleauthorJUNFENG XIA-
dc.contributor.googleauthorPEILIN JIA,-
dc.contributor.googleauthorHAILING JIN-
dc.contributor.googleauthorZHONGMING ZHAO-
dc.contributor.googleauthorWILLIAM PAO-
dc.contributor.googleauthorJEFFREY A. ENGELMAN-
dc.contributor.googleauthorA. JOHN IAFRATE-
dc.identifier.doi10.1634/theoncologist.2015-0510-
dc.contributor.localIdA02219-
dc.relation.journalcodeJ02415-
dc.identifier.pmid27022036-
dc.identifier.urlhttp://theoncologist.alphamedpress.org/content/21/4/481.abstract-
dc.subject.keywordLung cancer-
dc.subject.keywordMET exon 14 skipping-
dc.subject.keywordTargeted therapy-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.citation.volume21-
dc.citation.number4-
dc.citation.startPage481-
dc.citation.endPage486-
dc.identifier.bibliographicCitationOncologist, Vol.21(4) : 481-486, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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