185 211

Cited 8 times in

Risk Factors Associated with Loco-Regional Failure after Surgical Resection in Patients with Resectable Pancreatic Cancer.

DC FieldValueLanguage
dc.contributor.author강창무-
dc.contributor.author김현주-
dc.contributor.author방승민-
dc.contributor.author성진실-
dc.contributor.author송시영-
dc.contributor.author이우정-
dc.contributor.author황호경-
dc.date.accessioned2017-02-27T08:13:33Z-
dc.date.available2017-02-27T08:13:33Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147121-
dc.description.abstractPURPOSE: To evaluate the risk factors associated with loco-regional failure after surgical resection and to identify the subgroup that can obtain benefits from adjuvant radiotherapy (RT). MATERIALS AND METHODS: We identified patients treated with surgical resection for resectable pancreatic cancer at Severance hospital between January 1993 and December 2014. Patients who received any neoadjuvant or adjuvant RT were excluded. A total of 175 patients were included. Adjuvant chemotherapy was performed in 107 patients with either a gemcitabine-based regimen (65.4%) or 5-FU based one (34.9%). RESULTS: The median loco-regional failure-free survival (LRFFS) and overall survival (OS) were 23.9 and 33.6 months, respectively. A recurrence developed in 108 of 175 patients (61.7%). The predominant pattern of the first failure was distant (42.4%) and 47 patients (26.9%) developed local failure as the first site of recurrence. Multivariate analysis identified initial CA 19-9 ≥ 200 U/mL, N1 stage, perineural invasion (PNI), and resection margin as significant independent risk factors for LRFFS. Patients were divided into four groups according to the number of risk factors, including initial CA 19-9, N stage, and PNI. Patients exhibiting two risk factors had 3.2-fold higher loco-regional failure (P < 0.001) and patients with all risk factors showed a 6.5-fold increase (P < 0.001) compared with those with no risk factors. In the analysis for OS, patients with more than two risk factors also had 3.3- to 6-fold higher risk of death with statistical significance. CONCLUSION: The results suggest that patients who exhibit more than two risk factors have a higher risk of locoregional failure and death. This subgroup could be benefited by the effective local adjuvant treatment.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0157196-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/pathology*-
dc.subject.MESHPancreatic Neoplasms/surgery*-
dc.subject.MESHPrognosis-
dc.subject.MESHRisk Factors-
dc.titleRisk Factors Associated with Loco-Regional Failure after Surgical Resection in Patients with Resectable Pancreatic Cancer.-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorHyun Ju Kim-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorSeung Min Bang-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1371/journal.pone.0157196-
dc.contributor.localIdA00088-
dc.contributor.localIdA04551-
dc.contributor.localIdA01786-
dc.contributor.localIdA01956-
dc.contributor.localIdA02035-
dc.contributor.localIdA02993-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27332708-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameKim, Hyun Ju-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameHwang, Ho Kyoung-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorKim, Hyun Ju-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorHwang, Ho Kyoung-
dc.citation.volume11-
dc.citation.number6-
dc.citation.startPagee0157196-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(6) : e0157196, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.