285 272

Cited 9 times in

Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome After Shigellosis: A 10-year Follow-up Study.

Authors
 Young Hoon Youn  ;  Hyeon Chang Kim  ;  Hyun Chul Lim  ;  Jae Jun Park  ;  Jie-Hyun Kim  ;  Hyojin Park 
Citation
 JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.22(3) : 490-496, 2016 
Journal Title
 JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY 
ISSN
 2093-0879 
Issue Date
2016
Keywords
Cohort ; Dysentery ; Irritable bowel syndrome ; Prognosis ; Shigella
Abstract
BACKGROUND/AIMS: A limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. METHODS: A prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infected by Shigella sonnei due to contaminated food in the cafeteria, and 105 sex- and age-matched, non-infected, controls were serially followed for their bowel symptoms by questionnaire surveys for 10 years. RESULTS: The Shigella -infected cohort showed significantly higher odds ratio for irritable bowel syndrome (IBS) at 1-year (11.90; 95% CI, 1.49-95.58) and 3-year (3.93; 95% CI, 1.20-12.86) follow-up, compared to their controls. However, corresponding odds ratio for PI-IBS was not significantly increased at 5-year (1.88; 95% CI, 0.64-5.54) and 8-year (1.87; 95% CI, 0.62-5.19) follow-up. At 10-year follow-up survey, the prevalence of IBS was similar for the Shigella -infected cohort and their controls (23.3% versus 19.7%, P = 0.703). Risk factors which were independently associated with PI-IBS among the Shigella -infected cohort included younger age, previous history of functional bowel disorder, and longer duration of diarrhea at baseline. CONCLUSIONS: Patients who were infected by Shigella sonnei experienced significantly increased risk of IBS until 3 years after shigellosis, and modestly increased risk until 8 years, but showed similar risk of IBS with uninfected controls at 10 years post-infection. PI-IBS is quite a chronic disorder, and follows a long-term natural course.
Files in This Item:
T201602110.pdf Download
DOI
10.5056/jnm15157
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Park, Jae Jun(박재준)
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Lim, Hyun Chul(임현철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147114
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse