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Effect of End-Stage Renal Disease on Rate of Progression of Aortic Stenosis.

DC Field Value Language
dc.contributor.author김다래-
dc.contributor.author심지영-
dc.contributor.author장혁재-
dc.contributor.author정남식-
dc.contributor.author조인정-
dc.contributor.author하종원-
dc.contributor.author홍그루-
dc.date.accessioned2017-02-27T07:59:54Z-
dc.date.available2017-02-27T07:59:54Z-
dc.date.issued2016-
dc.identifier.issn0002-9149-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147052-
dc.description.abstractThis study aimed to investigate the progression of mild-to-moderate aortic stenosis (AS) in patients with end-stage renal disease (ESRD) and determine its metabolic and hemodynamic contributors and clinical outcomes. A total of 74 patients with ESRD (50 men, age 72 ± 11 years) with mild-to-moderate AS were compared with 79 age- and gender-matched controls with normal kidney function. Clinical, laboratory, and echocardiographic features and clinical outcomes including aortic valve (AV) intervention, hospitalization due to heart failure, and cardiovascular death were analyzed. Patients with ESRD were divided into 2 subgroups according to their rate of AV area changes (group 1 [n = 28], rapid progression; and group 2 [n = 46], slow progression). Progression in the degree of AS was noted in 38% of patients with ESRD and 18% of controls (p <0.01) during comparable echocardiographic follow-up durations (29 ± 15 vs 27 ± 24 months, respectively, p = 0.57). In ESRD, patients in group 1 were older (p <0.01) with higher baseline log parathyroid hormone (p <0.01) and larger stroke volume (p = 0.03) than those in group 2. During clinical follow-up (48 ± 23 months), patients in group 1 showed poorer clinical outcomes than those in group 2 and controls (log-rank p <0.01). Age, left atrial volume index ≥42 ml/m(2), and annual increases of peak pressure gradient across the AV (mm Hg/year) demonstrated additive predictive values for prognosis. AS in ESRD progresses in an accelerated manner along with higher metabolic and hemodynamic loads on AV compared with those with normal kidney function. Accelerated progression of mild-to-moderate AS in ESRD results in poor prognosis.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent1972~1977-
dc.publisherExcerpta Medica-
dc.relation.isPartOfAMERICAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAortic Valve Stenosis/complications*-
dc.subject.MESHAortic Valve Stenosis/diagnosis-
dc.subject.MESHAortic Valve Stenosis/physiopathology-
dc.subject.MESHDisease Progression-
dc.subject.MESHEchocardiography, Doppler-
dc.subject.MESHEchocardiography, Transesophageal-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHeart Ventricles/diagnostic imaging*-
dc.subject.MESHHeart Ventricles/physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHKidney Failure, Chronic/complications*-
dc.subject.MESHMale-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStroke Volume/physiology*-
dc.subject.MESHVentricular Function, Left/physiology*-
dc.titleEffect of End-Stage Renal Disease on Rate of Progression of Aortic Stenosis.-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDarae Kim-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorIn Jeong Cho-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi10.1016/j.amjcard.2016.03.048-
dc.contributor.localIdA00361-
dc.contributor.localIdA02213-
dc.contributor.localIdA03490-
dc.contributor.localIdA03585-
dc.contributor.localIdA03892-
dc.contributor.localIdA04257-
dc.contributor.localIdA04386-
dc.relation.journalcodeJ00071-
dc.identifier.eissn1879-1913-
dc.identifier.pmid27138183-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0002914916304350-
dc.contributor.alternativeNameKim, Da Rae-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCho, In Jeong-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.alternativeNameHong, Geu Ru-
dc.contributor.affiliatedAuthorKim, Da Rae-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorCho, In Jeong-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.contributor.affiliatedAuthorHong, Geu Ru-
dc.citation.volume117-
dc.citation.number12-
dc.citation.startPage1972-
dc.citation.endPage1977-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CARDIOLOGY, Vol.117(12) : 1972-1977, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47084-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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