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The prognostic significance of monoclonal immunoglobulin gene rearrangement in conjunction with histologic B-cell aggregates in the bone marrow of patients with diffuse large B-cell lymphoma.

DC Field Value Language
dc.contributor.author민유홍-
dc.contributor.author송재우-
dc.contributor.author양우익-
dc.contributor.author윤선옥-
dc.contributor.author조윤아-
dc.date.accessioned2017-02-27T07:58:19Z-
dc.date.available2017-02-27T07:58:19Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147046-
dc.description.abstractBone marrow involvement (BMI) is a well-known poor prognostic factor in patients with diffuse large B-cell lymphoma (DLBCL). This study robustly investigated the significance of monoclonal immunoglobulin gene rearrangement combined with histologic B-cell aggregates in bone marrow (BM) in the detection of a poor prognostic group. Pretreatment BM samples of 394 DLBCL patients were analyzed via the immunoglobulin gene rearrangement study and the microscopic examination. Monoclonal immunoglobulin gene rearrangement was detected in 25.4% of cases. Histologic B-cell aggregates with the features of large B-cell lymphoma aggregates, small cell B-cell lymphoma aggregates, or B-cell aggregates of unknown biological potential were observed in 12% of cases (6.9%, 1.3%, and 3.8%, respectively). Histologic B-cell aggregates were more associated with monoclonality than polyclonality. Cases with both monoclonality and histologic B-cell aggregates demonstrated close association with poor prognostic factors such as a higher International Prognostic Index score and showed an inferior overall survival rate when compared to cases with only monoclonality or only histologic B-cell aggregates. From the findings, a combination of monoclonality and histologic B-cell aggregates within the bone marrow was highly associated with poor prognosis and could be used to determine high-risk DLBLC patients with greater sensitivity and specificity than conventional microscopic examination or immunoglobulin gene rearrangement study alone.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1066~1073-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons Ltd.-
dc.relation.isPartOfCANCER MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHB-Lymphocytes/metabolism*-
dc.subject.MESHB-Lymphocytes/pathology*-
dc.subject.MESHBiomarkers-
dc.subject.MESHBone Marrow/pathology*-
dc.subject.MESHCell Aggregation-
dc.subject.MESHFemale-
dc.subject.MESHGene Rearrangement, B-Lymphocyte*-
dc.subject.MESHGenes, Immunoglobulin*-
dc.subject.MESHHumans-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse/diagnosis*-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse/genetics*-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse/mortality-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.titleThe prognostic significance of monoclonal immunoglobulin gene rearrangement in conjunction with histologic B-cell aggregates in the bone marrow of patients with diffuse large B-cell lymphoma.-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYoon Ah Cho-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorJae-Woo Song-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorSun Och Yoon-
dc.identifier.doi10.1002/cam4.679-
dc.contributor.localIdA01407-
dc.contributor.localIdA02054-
dc.contributor.localIdA02300-
dc.contributor.localIdA02566-
dc.contributor.localIdA04683-
dc.relation.journalcodeJ00449-
dc.identifier.eissn2045-7634-
dc.relation.journalsince2012~-
dc.identifier.pmid26923640-
dc.subject.keywordBone marrow-
dc.subject.keyworddiffuse large B-cell lymphoma-
dc.subject.keywordimmunoglobulin genes-
dc.subject.keywordlymphoid aggregates-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.alternativeNameCho, Yoon Ah-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorCho, Yoon Ah-
dc.citation.volume5-
dc.citation.number6-
dc.citation.startPage1066-
dc.citation.endPage1073-
dc.identifier.bibliographicCitationCANCER MEDICINE, Vol.5(6) : 1066-1073, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47078-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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