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Subclinical Hypothyroidism in Childhood Cancer Survivors.

DC Field Value Language
dc.contributor.author김선희-
dc.contributor.author김효선-
dc.contributor.author유철주-
dc.contributor.author이윤선-
dc.contributor.author이현주-
dc.contributor.author진송이-
dc.contributor.author한승민-
dc.contributor.author한정우-
dc.date.accessioned2017-02-27T07:56:09Z-
dc.date.available2017-02-27T07:56:09Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147038-
dc.description.abstractPURPOSE: In childhood cancer survivors, the most common late effect is thyroid dysfunction, most notably subclinical hypothyroidism (SCH). Our study evaluated the risk factors for persistent SCH in survivors. MATERIALS AND METHODS: Survivors (n=423) were defined as patients who survived at least 2 years after cancer treatment completion. Thyroid function was assessed at this time and several years thereafter. Two groups of survivors with SCH were compared: those who regained normal thyroid function during the follow-up period (normalized group) and those who did not (persistent group). RESULTS: Overall, 104 of the 423 survivors had SCH. SCH was observed in 26% of brain or nasopharyngeal cancer survivors (11 of 43) and 21.6% of leukemia survivors (35 of 162). Sixty-two survivors regained normal thyroid function, 30 remained as persistent SCH, and 12 were lost to follow-up. The follow-up duration was 4.03 (2.15-5.78) years. Brain or nasopharyngeal cancer and Hodgkin disease were more common in the persistent group than in the normalized group (p=0.002). More patients in the persistent group received radiation (p=0.008). Radiation to the head region was higher in this group (2394±2469 cGy) than in the normalized group (894±1591 cGy; p=0.003). On multivariable analysis, lymphoma (p=0.011), brain or nasopharyngeal cancer (p=0.039), and head radiation dose ≥1800 cGy (p=0.039) were significant risk factors for persistent SCH. CONCLUSION: SCH was common in childhood cancer survivors. Brain or nasopharyngeal cancer, lymphoma, and head radiation ≥1800 cGy were significant risk factors for persistent SCH.-
dc.description.statementOfResponsibilityopen-
dc.format.extent915~922-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge Factors-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypothyroidism/diagnosis*-
dc.subject.MESHHypothyroidism/etiology*-
dc.subject.MESHHypothyroidism/mortality-
dc.subject.MESHInfant-
dc.subject.MESHMale-
dc.subject.MESHNeoplasms/complications*-
dc.subject.MESHNeoplasms/mortality-
dc.subject.MESHNeoplasms/therapy-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvivors*-
dc.titleSubclinical Hypothyroidism in Childhood Cancer Survivors.-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeOthers-
dc.contributor.departmentSeverance Hospital-
dc.contributor.googleauthorHyun Joo Lee-
dc.contributor.googleauthorSeung Min Hahn-
dc.contributor.googleauthorSong Lee Jin-
dc.contributor.googleauthorYoon Jung Shin-
dc.contributor.googleauthorSun Hee Kim-
dc.contributor.googleauthorYoon Sun Lee-
dc.contributor.googleauthorHyo Sun Kim-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorJung Woo Han-
dc.identifier.doi10.3349/ymj.2016.57.4.915-
dc.contributor.localIdA04527-
dc.contributor.localIdA01201-
dc.contributor.localIdA02524-
dc.contributor.localIdA04634-
dc.contributor.localIdA04645-
dc.contributor.localIdA04688-
dc.contributor.localIdA04299-
dc.contributor.localIdA04325-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid27189285-
dc.subject.keywordHypothyroidism-
dc.subject.keywordchild-
dc.subject.keywordneoplasm-
dc.subject.keywordsurvivor-
dc.contributor.alternativeNameKim, Sun Hee-
dc.contributor.alternativeNameKim, Hyo Sun-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameRee, Yoon Sun-
dc.contributor.alternativeNameLee, Hyun Joo-
dc.contributor.alternativeNameJin, Song Lee-
dc.contributor.alternativeNameHahn, Seung Min-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorKim, Sun Hee-
dc.contributor.affiliatedAuthorKim, Hyo Sun-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorRee, Yoon Sun-
dc.contributor.affiliatedAuthorLee, Hyun Joo-
dc.contributor.affiliatedAuthorJin, Song Lee-
dc.contributor.affiliatedAuthorHahn, Seung Min-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.contributor.affiliatedAuthor이현주-
dc.citation.volume57-
dc.citation.number4-
dc.citation.startPage915-
dc.citation.endPage922-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.57(4) : 915-922, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47070-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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