Cited 9 times in
Subclinical Hypothyroidism in Childhood Cancer Survivors.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김선희 | - |
dc.contributor.author | 김효선 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 이윤선 | - |
dc.contributor.author | 이현주 | - |
dc.contributor.author | 진송이 | - |
dc.contributor.author | 한승민 | - |
dc.contributor.author | 한정우 | - |
dc.date.accessioned | 2017-02-27T07:56:09Z | - |
dc.date.available | 2017-02-27T07:56:09Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147038 | - |
dc.description.abstract | PURPOSE: In childhood cancer survivors, the most common late effect is thyroid dysfunction, most notably subclinical hypothyroidism (SCH). Our study evaluated the risk factors for persistent SCH in survivors. MATERIALS AND METHODS: Survivors (n=423) were defined as patients who survived at least 2 years after cancer treatment completion. Thyroid function was assessed at this time and several years thereafter. Two groups of survivors with SCH were compared: those who regained normal thyroid function during the follow-up period (normalized group) and those who did not (persistent group). RESULTS: Overall, 104 of the 423 survivors had SCH. SCH was observed in 26% of brain or nasopharyngeal cancer survivors (11 of 43) and 21.6% of leukemia survivors (35 of 162). Sixty-two survivors regained normal thyroid function, 30 remained as persistent SCH, and 12 were lost to follow-up. The follow-up duration was 4.03 (2.15-5.78) years. Brain or nasopharyngeal cancer and Hodgkin disease were more common in the persistent group than in the normalized group (p=0.002). More patients in the persistent group received radiation (p=0.008). Radiation to the head region was higher in this group (2394±2469 cGy) than in the normalized group (894±1591 cGy; p=0.003). On multivariable analysis, lymphoma (p=0.011), brain or nasopharyngeal cancer (p=0.039), and head radiation dose ≥1800 cGy (p=0.039) were significant risk factors for persistent SCH. CONCLUSION: SCH was common in childhood cancer survivors. Brain or nasopharyngeal cancer, lymphoma, and head radiation ≥1800 cGy were significant risk factors for persistent SCH. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 915~922 | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypothyroidism/diagnosis* | - |
dc.subject.MESH | Hypothyroidism/etiology* | - |
dc.subject.MESH | Hypothyroidism/mortality | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasms/complications* | - |
dc.subject.MESH | Neoplasms/mortality | - |
dc.subject.MESH | Neoplasms/therapy | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Survivors* | - |
dc.title | Subclinical Hypothyroidism in Childhood Cancer Survivors. | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | Others | - |
dc.contributor.department | Severance Hospital | - |
dc.contributor.googleauthor | Hyun Joo Lee | - |
dc.contributor.googleauthor | Seung Min Hahn | - |
dc.contributor.googleauthor | Song Lee Jin | - |
dc.contributor.googleauthor | Yoon Jung Shin | - |
dc.contributor.googleauthor | Sun Hee Kim | - |
dc.contributor.googleauthor | Yoon Sun Lee | - |
dc.contributor.googleauthor | Hyo Sun Kim | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.identifier.doi | 10.3349/ymj.2016.57.4.915 | - |
dc.contributor.localId | A04527 | - |
dc.contributor.localId | A01201 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A04634 | - |
dc.contributor.localId | A04645 | - |
dc.contributor.localId | A04688 | - |
dc.contributor.localId | A04299 | - |
dc.contributor.localId | A04325 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 27189285 | - |
dc.subject.keyword | Hypothyroidism | - |
dc.subject.keyword | child | - |
dc.subject.keyword | neoplasm | - |
dc.subject.keyword | survivor | - |
dc.contributor.alternativeName | Kim, Sun Hee | - |
dc.contributor.alternativeName | Kim, Hyo Sun | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Ree, Yoon Sun | - |
dc.contributor.alternativeName | Lee, Hyun Joo | - |
dc.contributor.alternativeName | Jin, Song Lee | - |
dc.contributor.alternativeName | Hahn, Seung Min | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Kim, Sun Hee | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Sun | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Ree, Yoon Sun | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Joo | - |
dc.contributor.affiliatedAuthor | Jin, Song Lee | - |
dc.contributor.affiliatedAuthor | Hahn, Seung Min | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | 이현주 | - |
dc.citation.volume | 57 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 915 | - |
dc.citation.endPage | 922 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(4) : 915-922, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47070 | - |
dc.type.rims | ART | - |
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