Cited 21 times in
Association of serum adiponectin level with albuminuria in chronic kidney disease patients.
DC Field | Value | Language |
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dc.contributor.author | 최규헌 | - |
dc.date.accessioned | 2017-02-27T07:55:14Z | - |
dc.date.available | 2017-02-27T07:55:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1342-1751 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147032 | - |
dc.description.abstract | BACKGROUND: Adiponectin, a peptide hormone secreted from adipocytes, exerts anti-diabetic, anti-atherogenic, and anti-inflammatory properties. We aimed to determine the relationship between serum adiponectin levels and albuminuria, and evaluate determinant factors for serum adiponectin in patients with chronic kidney disease (CKD). METHODS: In total, 1442 CKD patients were included and divided into three groups according to their albumin-to-creatinine ratios: patients with normoalbuminuria (N = 228), microalbuminuria (N = 444), and macroalbuminuria (N = 761). Serum adiponectin was specifically assayed with a commercially available enzyme-linked immunosorbent assay kit. RESULTS: Serum adiponectin was significantly higher in patients with macroalbuminuria than in those without macroalbuminuria (9.7 ± 6.0, 12.4 ± 9.0, and 14.9 ± 11.0 μg/mL in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria, respectively). Univariate linear regression analysis showed that the serum adiponectin concentrations were correlated with age, the albumin-to-creatinine ratio, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, whereas they were negatively correlated with body mass index, the estimated glomerular filtration rate, and serum albumin and triglyceride levels. The stepwise regression multiple analysis showed that sex; the estimated glomerular filtration rate; body mass index; total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels; and logarithm of the albumin-to-creatinine ratio were independently associated with the logarithm of serum adiponectin levels (r = 0.55, p < 0.001). CONCLUSION: Serum adiponectin concentrations are higher in patients with increasing albuminuria, and these levels are associated with renal insufficiency and lipid profiles. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 443~449 | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipokines/blood* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Albuminuria/blood* | - |
dc.subject.MESH | Albuminuria/diagnosis | - |
dc.subject.MESH | Albuminuria/etiology | - |
dc.subject.MESH | Albuminuria/urine | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Biomarkers/urine | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Creatinine/urine | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Lipids/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Renal Insufficiency, Chronic/blood* | - |
dc.subject.MESH | Renal Insufficiency, Chronic/complications | - |
dc.subject.MESH | Renal Insufficiency, Chronic/diagnosis | - |
dc.subject.MESH | Renal Insufficiency, Chronic/urine | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Young Adult | - |
dc.title | Association of serum adiponectin level with albuminuria in chronic kidney disease patients. | - |
dc.type | Article | - |
dc.publisher.location | Japan | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Ha Yeon Kim | - |
dc.contributor.googleauthor | Eun Hui Bae | - |
dc.contributor.googleauthor | Seong Kwon Ma | - |
dc.contributor.googleauthor | Dong Wan Chae | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Yong-Soo Kim | - |
dc.contributor.googleauthor | Young-Hwan Hwang | - |
dc.contributor.googleauthor | Curie Ahn | - |
dc.contributor.googleauthor | Soo Wan Kim | - |
dc.identifier.doi | 10.1007/s10157-015-1173-4 | - |
dc.contributor.localId | A04043 | - |
dc.relation.journalcode | J00551 | - |
dc.identifier.pmid | 26445954 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s10157-015-1173-4 | - |
dc.subject.keyword | Albuminuria | - |
dc.subject.keyword | Chronic kidney disease | - |
dc.subject.keyword | Serum adiponectin | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 443 | - |
dc.citation.endPage | 449 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL NEPHROLOGY, Vol.20(3) : 443-449, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47064 | - |
dc.type.rims | ART | - |
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