Cited 15 times in
Re-Irradiation for Recurrent Gliomas: Treatment Outcomes and Prognostic Factors.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 이정심 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 조재호 | - |
dc.date.accessioned | 2017-02-27T07:48:06Z | - |
dc.date.available | 2017-02-27T07:48:06Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146992 | - |
dc.description.abstract | PURPOSE: The aim of this study was to evaluate the efficacy of re-irradiation in patients with recurrent gliomas and to identify subgroups for whom re-irradiation for recurrent gliomas is most beneficial. MATERIALS AND METHODS: We retrospectively reviewed 36 patients with recurrent or progressive gliomas who received re-irradiation between January 1996 and December 2011. Re-irradiation was offered to recurrent glioma patients with good performance or at least 6 months had passed after initial radiotherapy (RT), with few exceptions. RESULTS: Median doses of re-irradiation and initial RT were 45.0 Gy and 59.4 Gy, respectively. The median time interval between initial RT and re-irradiation was 30.5 months. Median overall survival (OS) and the 12-month OS rate were 11 months and 41.7%, respectively. In univariate analysis, Karnofsky performance status (KPS) ≥70 (p<0.001), re-irradiation dose ≥45 Gy (p=0.040), and longer time interval between initial RT and re-irradiation (p=0.040) were associated with improved OS. In multivariate analysis, KPS (p=0.030) and length of time interval between initial RT and re-irradiation (p=0.048) were important predictors of OS. A radiographically suspected mixture of radiation necrosis and progression after re-irradiation was seen in 5 patients. CONCLUSION: Re-irradiation in conjunction with surgery could be a salvage treatment for selected recurrent glioma patients with good performance status and recurrence over a long time. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 824~830 | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Brain Neoplasms/mortality | - |
dc.subject.MESH | Brain Neoplasms/radiotherapy* | - |
dc.subject.MESH | Brain Neoplasms/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glioma/mortality | - |
dc.subject.MESH | Glioma/radiotherapy* | - |
dc.subject.MESH | Glioma/surgery | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Karnofsky Performance Status | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality | - |
dc.subject.MESH | Neoplasm Recurrence, Local/radiotherapy* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/surgery | - |
dc.subject.MESH | Re-Irradiation* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Salvage Therapy | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Re-Irradiation for Recurrent Gliomas: Treatment Outcomes and Prognostic Factors. | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Jeongshim Lee | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.identifier.doi | 10.3349/ymj.2016.57.4.824 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A03112 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A03901 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 27189273 | - |
dc.subject.keyword | Re-irradiation | - |
dc.subject.keyword | prognostic factor | - |
dc.subject.keyword | recurrent glioma | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Lee, Jeong Shim | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Shim | - |
dc.contributor.affiliatedAuthor | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.citation.volume | 57 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 824 | - |
dc.citation.endPage | 830 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(4) : 824-830, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47025 | - |
dc.type.rims | ART | - |
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