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Role of Thalidomide on the Expression of OX40, 4-1BB, and GITR in T Cell Subsets
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2017-02-27T07:44:46Z | - |
dc.date.available | 2017-02-27T07:44:46Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146979 | - |
dc.description.abstract | BACKGROUND: Thalidomide (TM) is known to have anti-cancer and anti-inflammatory properties; however, its mechanism on T cells is still unclear. We previously showed the immune modulatory effect of TM on T cells and its therapeutic effect on lupus nephritis models. Here we examined the changes in the expression of tumor necrosis factor receptor superfamilies (TNFRSFs), including OX40, 4-1BB, and glucocorticoid-induced TNFR-related protein (GITR) in T cell subsets by TM treatments. METHODS: Splenic naïve T cells (Tnaives) from C57BL/6 mice were sort-purified and cultured for CD4(+) T cell proliferation and regulatory T cells (Tregs) conversion with TM treatments. All samples were analyzed by flow cytometry after stained with anti-mouse CD4, Foxp3, OX40, 4-1BB, or GITR antibodies. RESULTS: Expressions of OX40, 4-1BB, and GITR on CD4(+) T cells showed a decreasing tendency by TM treatments. Especially, downregulation of these molecules on CD4(+)CFSE(low) T cells was significant in TM treatment groups. On the condition of Treg conversion, OX40 was downregulated significantly. In contrast, the expression of GITR was increased, and that of 4-1BB had shown no particular change under the condition of Treg. CONCLUSION: Considering these results, TM may have an immune modulatory role through the T cell subset-specific change of OX40, 4-1BB, and GITR expression. Further study is required to elucidate the effect of thalidomide on T cells. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 1270~1274 | - |
dc.language | English | - |
dc.publisher | Elsevier Science Inc. | - |
dc.relation.isPartOf | TRANSPLANTATION PROCEEDINGS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 4-1BB Ligand/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Glucocorticoid-Induced TNFR-Related Protein/metabolism* | - |
dc.subject.MESH | Immunosuppressive Agents/pharmacology* | - |
dc.subject.MESH | Lymphocyte Activation/drug effects | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Receptors, OX40/metabolism* | - |
dc.subject.MESH | Receptors, Tumor Necrosis Factor/metabolism | - |
dc.subject.MESH | Spleen/immunology | - |
dc.subject.MESH | T-Lymphocyte Subsets/drug effects* | - |
dc.subject.MESH | T-Lymphocyte Subsets/immunology | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/drug effects | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/immunology | - |
dc.subject.MESH | Thalidomide/pharmacology* | - |
dc.title | Role of Thalidomide on the Expression of OX40, 4-1BB, and GITR in T Cell Subsets | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | B.S. Kim | - |
dc.contributor.googleauthor | J.Y. Kim | - |
dc.contributor.googleauthor | E.J. Kim | - |
dc.contributor.googleauthor | J.G. Lee | - |
dc.contributor.googleauthor | D.J. Joo | - |
dc.contributor.googleauthor | K.H. Huh | - |
dc.contributor.googleauthor | M.S. Kim | - |
dc.contributor.googleauthor | Y.S. Kim | - |
dc.identifier.doi | 10.1016/j.transproceed.2015.12.088 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J02755 | - |
dc.identifier.eissn | 1873-2623 | - |
dc.identifier.pmid | 27320601 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0041134516001895 | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Lee, Jae Geun | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Lee, Jae Geun | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.citation.volume | 48 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1270 | - |
dc.citation.endPage | 1274 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, Vol.48(4) : 1270-1274, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46543 | - |
dc.type.rims | ART | - |
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