Cited 13 times in
Distinctive expression patterns of hypoxia-inducible factor-1α and endothelial nitric oxide synthase following hypergravity exposure.
DC Field | Value | Language |
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dc.contributor.author | 김현수 | - |
dc.date.accessioned | 2017-02-27T07:43:03Z | - |
dc.date.available | 2017-02-27T07:43:03Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146969 | - |
dc.description.abstract | This study was designed to examine the expression of hypoxia-inducible factor-1α (HIF-1α) and the level and activity of endothelial nitric oxide synthase (eNOS) in the hearts and livers of mice exposed to hypergravity. Hypergravity-induced hypoxia and the subsequent post-exposure reoxygenation significantly increased cardiac HIF-1α levels. Furthermore, the levels and activity of cardiac eNOS also showed significant increase immediately following hypergravity exposure and during the reoxygenation period. In contrast, the expression of phosphorylated Akt (p-Akt) and phosphorylated extracellular signal-regulated kinase (p-ERK) showed significant elevation only during the reoxygenation period. These data raise the possibility that the increase in cardiac HIF-1α expression induced by reoxygenation involves a cascade of signaling events, including activation of the Akt and ERK pathways. In the liver, HIF-1α expression was significantly increased immediately after hypergravity exposure, indicating that hypergravity exposure to causes hepatocellular hypoxia. The hypergravity-exposed livers showed significantly higher eNOS immunoreactivity than did those of control mice. Consistent with these results, significant increases in eNOS activity and nitrate/nitrite levels were also observed. These findings suggest that hypergravity-induced hypoxia plays a significant role in the upregulation of hepatic eNOS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33675~33688 | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Hypergravity/adverse effects* | - |
dc.subject.MESH | Hypoxia/etiology | - |
dc.subject.MESH | Hypoxia/metabolism* | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis* | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Myocardium/metabolism | - |
dc.subject.MESH | Nitric Oxide Synthase Type III/biosynthesis* | - |
dc.title | Distinctive expression patterns of hypoxia-inducible factor-1α and endothelial nitric oxide synthase following hypergravity exposure. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Gun Yoon | - |
dc.contributor.googleauthor | Choong Sik Oh | - |
dc.contributor.googleauthor | Hyun-Soo Kim | - |
dc.identifier.doi | 10.18632/oncotarget.9372 | - |
dc.contributor.localId | A01114 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27191892 | - |
dc.subject.keyword | Pathology Section | - |
dc.subject.keyword | endothelial nitric oxide synthase | - |
dc.subject.keyword | heart | - |
dc.subject.keyword | hypergravity | - |
dc.subject.keyword | hypoxia-inducible factor-1α | - |
dc.subject.keyword | liver | - |
dc.contributor.alternativeName | Kim, Hyun-Soo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Soo | - |
dc.citation.volume | 7 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 33675 | - |
dc.citation.endPage | 33688 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.7(23) : 33675-33688, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46533 | - |
dc.type.rims | ART | - |
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