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Correlation between conductivity and prognostic factors in invasive breast cancer using magnetic resonance electric properties tomography (MREPT).

Authors
 Soo-Yeon Kim  ;  Jaewook Shin  ;  Dong-Hyun Kim  ;  Min Jung Kim  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon 
Citation
 EUROPEAN RADIOLOGY, Vol.26(7) : 2317-2326, 2016 
Journal Title
 EUROPEAN RADIOLOGY 
ISSN
 0938-7994 
Issue Date
2016
MeSH
Adult ; Aged ; Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnostic imaging* ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/diagnostic imaging* ; Carcinoma, Ductal, Breast/pathology ; Electric Conductivity* ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods* ; Magnetic Resonance Imaging/methods* ; Middle Aged ; Prognosis ; Reproducibility of Results ; Retrospective Studies
Keywords
Breast cancer ; Electric conductivity ; HER-2 ; Magnetic resonance imaging ; Mitosis
Abstract
PURPOSE: To investigate the correlation between conductivity and prognostic factors of invasive breast cancer using magnetic resonance electric properties tomography (MREPT). METHODS: This retrospective study was approved by the Institutional Review Board, and verbal informed consent was obtained prior to breast MRI. This study included 65 women with surgically confirmed invasive breast cancers measuring 1 cm or larger on T2-weighted fast spin echo (FSE). Phase-based MREPT and the coil combination technique were used to reconstruct conductivity. Simple and multiple linear regression analysis were used to find an independent factor associated with conductivity. RESULTS: In total tumours, tumours with HER-2 overexpression showed lower conductivity than those without, and HER-2 overexpression was independently associated with conductivity. In 37 tumours 2 cm or larger, tumours with high mitosis or PR positivity showed higher conductivity than those without, and high mitosis and PR positivity were independently associated with conductivity. In 28 tumours 1-2 cm in size, there were no differences in conductivity according to the prognostic factors. CONCLUSION: Conductivity values measured using MREPT are associated with the HER-2 overexpression status, and may provide information about mitosis and the PR status of invasive breast cancers 2 cm or larger. KEY POINTS: In all tumours, HER-2 overexpression was independently associated with conductivity. • In tumours ≥ 2 cm, high mitosis and PR positivity were associated with conductivity. • Conductivity is associated with the HER-2 overexpression status of invasive breast cancers.
Full Text
http://link.springer.com/article/10.1007/s00330-015-4067-7
DOI
10.1007/s00330-015-4067-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146958
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