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Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease

DC Field Value Language
dc.contributor.author김종윤-
dc.contributor.author김태훈-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.date.accessioned2017-02-27T07:33:15Z-
dc.date.available2017-02-27T07:33:15Z-
dc.date.issued2016-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146910-
dc.description.abstractBACKGROUND: Systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). However, little evidence exists whether the risk of AF is increased in autoimmune rheumatic disease (ARD). METHODS: In 20,772 consecutive ARD patients (mean age 42±17years, 13,683 female) in a tertiary hospital from 2005 to 2015, AF prevalence, comorbidities and cardiovascular (CV) outcomes were evaluated. RESULTS: AF was observed in 235 (1.1%) patients. The mean duration to AF diagnoses was 5.9±2.4years. Compared with patients without AF, AF patients were older, and had a higher CRP level (5.1±0.7 vs. 2.7±0.2mg/L, p=0.01), higher incidence of hypertension, heart failure and coronary artery disease. The AF prevalence was higher in inflammatory myositis (3.5%) and systemic sclerosis (2.3%) than that in other ARDs (all p<0.05). In the multivariate analysis, the independent predictors of AF were an older age (HR 1.05, 95% CI: 1.04-1.06, p=0.01), hypertension (HR 2.28, 95% CI: 1.70-3.06, p<0.001), high CRP levels (HR 1.75, 95% CI: 1.07-2.86, p=0.04), and heart failure (HR 11.96, 95% CI: 8.13-17.60, p=0.03). During a mean follow-up period of 6.8±4.5years, ARD patients with AF had a higher all cause death (16.5% vs. 2.1%, p<0.001) and incidence of strokes (1.9% vs. 0.4%, p=0.001) than non-AF patients. CONCLUSIONS: The incidence of AF in ARD was affected by specific disease and an inflammatory status manifested by the CRP level. AF in ARD was related to a higher mortality and strokes mandating meticulous follow-up.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent4~9-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAtrial Fibrillation/epidemiology*-
dc.subject.MESHAtrial Fibrillation/metabolism-
dc.subject.MESHAutoimmune Diseases/epidemiology*-
dc.subject.MESHAutoimmune Diseases/metabolism-
dc.subject.MESHC-Reactive Protein/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRheumatic Diseases/epidemiology*-
dc.subject.MESHRheumatic Diseases/metabolism-
dc.subject.MESHRisk Factors-
dc.subject.MESHTertiary Care Centers/statistics & numerical data-
dc.titlePrevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYong-Soo Baek-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorJong-Yun Kim-
dc.contributor.googleauthorHui-Nam Pak-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorBoyoung Joung-
dc.identifier.doi10.1016/j.ijcard.2016.03.083-
dc.contributor.localIdA00926-
dc.contributor.localIdA01085-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ01093-
dc.identifier.eissn1874-1754-
dc.identifier.pmid27055157-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167527316305058-
dc.subject.keywordAtrial fibrillation-
dc.subject.keywordAutoimmune rheumatic disease-
dc.subject.keywordDeath-
dc.subject.keywordInflammation-
dc.subject.keywordStroke-
dc.contributor.alternativeNameKim, Jong Youn-
dc.contributor.alternativeNameKim, Tae Hoon-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.affiliatedAuthorKim, Jong Youn-
dc.contributor.affiliatedAuthorKim, Tae-Hoon-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.citation.volume214-
dc.citation.startPage4-
dc.citation.endPage9-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.214 : 4-9, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid46476-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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