Cited 23 times in
Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease
DC Field | Value | Language |
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dc.contributor.author | 김종윤 | - |
dc.contributor.author | 김태훈 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2017-02-27T07:33:15Z | - |
dc.date.available | 2017-02-27T07:33:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146910 | - |
dc.description.abstract | BACKGROUND: Systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). However, little evidence exists whether the risk of AF is increased in autoimmune rheumatic disease (ARD). METHODS: In 20,772 consecutive ARD patients (mean age 42±17years, 13,683 female) in a tertiary hospital from 2005 to 2015, AF prevalence, comorbidities and cardiovascular (CV) outcomes were evaluated. RESULTS: AF was observed in 235 (1.1%) patients. The mean duration to AF diagnoses was 5.9±2.4years. Compared with patients without AF, AF patients were older, and had a higher CRP level (5.1±0.7 vs. 2.7±0.2mg/L, p=0.01), higher incidence of hypertension, heart failure and coronary artery disease. The AF prevalence was higher in inflammatory myositis (3.5%) and systemic sclerosis (2.3%) than that in other ARDs (all p<0.05). In the multivariate analysis, the independent predictors of AF were an older age (HR 1.05, 95% CI: 1.04-1.06, p=0.01), hypertension (HR 2.28, 95% CI: 1.70-3.06, p<0.001), high CRP levels (HR 1.75, 95% CI: 1.07-2.86, p=0.04), and heart failure (HR 11.96, 95% CI: 8.13-17.60, p=0.03). During a mean follow-up period of 6.8±4.5years, ARD patients with AF had a higher all cause death (16.5% vs. 2.1%, p<0.001) and incidence of strokes (1.9% vs. 0.4%, p=0.001) than non-AF patients. CONCLUSIONS: The incidence of AF in ARD was affected by specific disease and an inflammatory status manifested by the CRP level. AF in ARD was related to a higher mortality and strokes mandating meticulous follow-up. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 4~9 | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrial Fibrillation/epidemiology* | - |
dc.subject.MESH | Atrial Fibrillation/metabolism | - |
dc.subject.MESH | Autoimmune Diseases/epidemiology* | - |
dc.subject.MESH | Autoimmune Diseases/metabolism | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Rheumatic Diseases/epidemiology* | - |
dc.subject.MESH | Rheumatic Diseases/metabolism | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tertiary Care Centers/statistics & numerical data | - |
dc.title | Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Yong-Soo Baek | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Jong-Yun Kim | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.1016/j.ijcard.2016.03.083 | - |
dc.contributor.localId | A00926 | - |
dc.contributor.localId | A01085 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 27055157 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167527316305058 | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | Autoimmune rheumatic disease | - |
dc.subject.keyword | Death | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Stroke | - |
dc.contributor.alternativeName | Kim, Jong Youn | - |
dc.contributor.alternativeName | Kim, Tae Hoon | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Uhm, Jae Sun | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Jong Youn | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hoon | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Uhm, Jae Sun | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.citation.volume | 214 | - |
dc.citation.startPage | 4 | - |
dc.citation.endPage | 9 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.214 : 4-9, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46476 | - |
dc.type.rims | ART | - |
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