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The effect of rituximab dose on infectious complications in ABO-incompatible kidney transplantation.

DC Field Value Language
dc.contributor.author김명수-
dc.contributor.author허규하-
dc.contributor.author김범석-
dc.contributor.author김순일-
dc.contributor.author김신영-
dc.contributor.author김유선-
dc.contributor.author김현옥-
dc.contributor.author송승환-
dc.contributor.author이재근-
dc.date.accessioned2017-02-27T07:27:36Z-
dc.date.available2017-02-27T07:27:36Z-
dc.date.issued2016-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146888-
dc.description.abstractBACKGROUND: Rituximab (RIT) improves the outcomes of ABO-incompatible (ABOi) kidney transplantation (KT), but it has been associated with infectious complications. The aim of this study was to investigate infectious complications according to the dose of RIT in ABOi KT. METHODS: We analyzed 213 recipients [118 ABO-compatible (ABOc) KT and 95 ABOi KT] who underwent living donor KT between 2010 and 2014. ABOi KT patients were categorized by RIT dose: standard RIT (375 mg/m(2), n = 76) versus reduced RIT (200 mg, n = 19). All patients received basiliximab and maintained on triple immunosuppression consisting of tacrolimus, prednisone and mycophenolate mofetil. Infectious complications and post-transplant outcomes were analyzed for 1 year following KT. RESULTS: The rates of overall infectious complications among the three groups were comparable (22.9% in ABOc KT, 38.2% in standard RIT and 26.3% in reduced RIT, P = 0.069). In the standard RIT group, hepatitis B virus reactivation occurred in three recipients (3.9%) with hepatitis B surface antigen[-]/anti-hepatitis B core antibody[+]. Three cases (3.9%) of Pneumocystis jirovecii pneumonia occurred in the standard RIT group. Serious infections developed in 13 of the ABOc KT (11.0%), 20 from the standard RIT group (26.3%) and 2 from the reduced RIT group (10.5%, P = 0.015). Standard-dose RIT was found to be an independent risk factor for serious infections [hazard ratio: 2.59 (95% confidence interval: 1.33-5.07), P = 0.005]. There were no significant differences in rejection, renal function, graft survival and patient survival between standard and reduced RIT groups. CONCLUSIONS: Standard RIT increased the risk of serious infection when compared with reduced-dose RIT. Reduced-dose RIT might be sufficient for ABOi KT without increasing the risk of serious infection.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent1013~1021-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNEPHROLOGY DIALYSIS TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHABO Blood-Group System/immunology*-
dc.subject.MESHAdult-
dc.subject.MESHBlood Group Incompatibility/complications*-
dc.subject.MESHBlood Group Incompatibility/immunology-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFemale-
dc.subject.MESHGraft Survival-
dc.subject.MESHHumans-
dc.subject.MESHImmunologic Factors/administration & dosage-
dc.subject.MESHImmunosuppression/methods*-
dc.subject.MESHKidney Transplantation/adverse effects*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRisk Factors-
dc.subject.MESHRituximab/administration & dosage*-
dc.subject.MESHSurgical Wound Infection/drug therapy*-
dc.titleThe effect of rituximab dose on infectious complications in ABO-incompatible kidney transplantation.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJuhan Lee-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorSinyoung Kim-
dc.contributor.googleauthorSeung Hwan Song-
dc.contributor.googleauthorBeom Seok Kim-
dc.contributor.googleauthorHyun Ok Kim-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorKyu Ha Huh-
dc.identifier.doi10.1093/ndt/gfw017-
dc.contributor.localIdA00424-
dc.contributor.localIdA04344-
dc.contributor.localIdA00488-
dc.contributor.localIdA00649-
dc.contributor.localIdA00675-
dc.contributor.localIdA00785-
dc.contributor.localIdA01122-
dc.contributor.localIdA02034-
dc.contributor.localIdA03068-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid27190360-
dc.identifier.urlhttp://ndt.oxfordjournals.org/content/31/6/1013-
dc.subject.keywordABO incompatibility-
dc.subject.keyworddesensitization-
dc.subject.keywordinfection-
dc.subject.keywordkidney transplantation-
dc.subject.keywordrituximab-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Sin Young-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.alternativeNameSong, Seung Hwan-
dc.contributor.alternativeNameLee, Jae Geun-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Sin Young-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.contributor.affiliatedAuthorSong, Seung Hwan-
dc.contributor.affiliatedAuthorLee, Jae Geun-
dc.citation.volume31-
dc.citation.number6-
dc.citation.startPage1013-
dc.citation.endPage1021-
dc.identifier.bibliographicCitationNEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.31(6) : 1013-1021, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid46455-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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