Cited 28 times in
Biomarkers for Bisphosphonate-Related Osteonecrosis of the Jaw
DC Field | Value | Language |
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dc.contributor.author | 차인호 | - |
dc.date.accessioned | 2017-02-24T11:44:56Z | - |
dc.date.available | 2017-02-24T11:44:56Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1523-0899 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146847 | - |
dc.description.abstract | PURPOSE: The aim of this study was to investigate a possible biomarker for bisphosphonate-related osteonecrosis of the jaw (BRONJ) in an animal model. MATERIALS AND METHODS: Forty-eight Sprague-Dawley rats were randomly divided into the bisphosphonate group (n = 36), who were injected once a week with zoledronic acid, and the control group (n = 12), who were injected once a week with saline. After 6 weeks, surgical intervention was performed, and injections were continued up to 8 weeks. Rats in the bisphosphonate group were then further classified to the ONJ group, and the non-ONJ group, and biomarkers, including CTx, Glu-OC, TRACP 5b, RANKL, and OPG, were assessed at baseline (T0), at surgical intervention (T1), and at sacrifice (T2). Histomorphometric analysis for quantification of osteoclasts was performed. RESULTS: Repeated measures analysis of variance revealed that TRACP 5b levels and the RANKL/OPG ratio were significantly decreased over time in the ONJ group compared with the non-ONJ group (p < .05). At T2, the area under the curve was 0.807 for TRACP 5b (sensitivity: 88.9%, specificity 66.7% at cutoff) and 0.765 for the RANKL/OPG ratio (sensitivity: 77.8%, specificity 62.9% at cutoff). TRACP 5b showed a lower least significant change (29.6%) with lower intra-assay coefficient of variability (CV; 6.32%) and interassay CV (11.20%) compared with those of the RANKL/OPG ratio (39.27%) and showed a higher signal-to-noise ratio (2.76) than that of the RANKL/OPG ratio (1.62). N.Oc/T.Ar and N.Oc/B.Ar demonstrated significantly decreased number of osteoclasts in ONJ group versus non-ONJ group. CONCLUSIONS: These results show that serum TRACP 5b and the RANKL/OPG ratio were possible biomarkers for BRONJ. These data may provide useful additional information for future ONJ research. Further studies are needed to validate these results in humans with ONJ. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 281~291 | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons, Inc | - |
dc.relation.isPartOf | CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers* | - |
dc.subject.MESH | Bisphosphonate-Associated Osteonecrosis of the Jaw* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Osteoclasts | - |
dc.subject.MESH | Osteonecrosis | - |
dc.subject.MESH | RANK Ligand/analysis* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Tartrate-Resistant Acid Phosphatase/analysis* | - |
dc.title | Biomarkers for Bisphosphonate-Related Osteonecrosis of the Jaw | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery | - |
dc.contributor.googleauthor | Jin-Woo Kim | - |
dc.contributor.googleauthor | In-Ho Cha | - |
dc.contributor.googleauthor | Sun-Jong Kim | - |
dc.contributor.googleauthor | Myung-Rae Kim | - |
dc.identifier.doi | 10.1111/cid.12297 | - |
dc.contributor.localId | A04002 | - |
dc.relation.journalcode | J00580 | - |
dc.identifier.eissn | 1708-8208 | - |
dc.identifier.pmid | 25726720 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/cid.12297/abstract | - |
dc.subject.keyword | biomarker | - |
dc.subject.keyword | bisphosphonate | - |
dc.subject.keyword | osteonecrosis of the jaw | - |
dc.subject.keyword | receptor activator of nuclear factor-κβ ligand | - |
dc.subject.keyword | tartrate-resistant acid phosphatase | - |
dc.contributor.alternativeName | Cha, In Ho | - |
dc.contributor.affiliatedAuthor | Cha, In Ho | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 281 | - |
dc.citation.endPage | 291 | - |
dc.identifier.bibliographicCitation | CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Vol.18(2) : 281-291, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47942 | - |
dc.type.rims | ART | - |
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