Cited 13 times in
Association between the Catechol-O-Methyltransferase (COMT) Val¹⁵⁸Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder.
DC Field | Value | Language |
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dc.contributor.author | 강지인 | - |
dc.contributor.author | 김세주 | - |
dc.contributor.author | 남궁기 | - |
dc.date.accessioned | 2017-02-24T11:43:04Z | - |
dc.date.available | 2017-02-24T11:43:04Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146840 | - |
dc.description.abstract | PURPOSE: Alexithymia, defined as a deficit in the ability to recognize and describe one's own feelings, may be related to the development and maintenance of obsessive-compulsive symptoms. The aim of this study was to evaluate the association between the catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism and alexithymia in patients with obsessive-compulsive disorder (OCD). MATERIALS AND METHODS: We recruited 244 patients with OCD (169 males, 75 females). Alexithymia was assessed using the 20-item Toronto Alexithymia Scale (TAS-20), and genotyping of the COMT Val¹⁵⁸Met polymorphism was evaluated. RESULTS: Patients with the COMT Val/Val genotype had significantly higher total and "difficulty identifying feelings" (DIF) subdimension scores than those with the Val/Met or Met/Met genotypes. Patients with the COMT Val/Val genotype had significantly higher "difficulty describing feelings" (DDF) subdimension scores than those with the COMT Val/Met genotype. However, there were no differences in the scores for the "externally oriented thinking" (EOT) subdimension among the three genotypes. CONCLUSION: These results indicate that the high-activity Val allele of the COMT Val¹⁵⁸Met polymorphism is associated with increased alexithymic traits in patients with OCD. The present finding suggests that alexithymia is an endophenotype of OCD that is mediated by the COMT Val¹⁵⁸Met polymorphism. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 721~727 | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Affective Symptoms/diagnosis* | - |
dc.subject.MESH | Affective Symptoms/genetics | - |
dc.subject.MESH | Affective Symptoms/psychology | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Catechol O-Methyltransferase/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obsessive-Compulsive Disorder/diagnosis* | - |
dc.subject.MESH | Obsessive-Compulsive Disorder/genetics | - |
dc.subject.MESH | Obsessive-Compulsive Disorder/psychology | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Association between the Catechol-O-Methyltransferase (COMT) Val¹⁵⁸Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder. | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Psychiatry | - |
dc.contributor.googleauthor | Min Jung Koh | - |
dc.contributor.googleauthor | Jee In Kang | - |
dc.contributor.googleauthor | Kee Namkoong | - |
dc.contributor.googleauthor | Su Young Lee | - |
dc.contributor.googleauthor | Se Joo Kim | - |
dc.identifier.doi | 10.3349/ymj.2016.57.3.721 | - |
dc.contributor.localId | A00084 | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01240 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 26996573 | - |
dc.subject.keyword | Alexithymia | - |
dc.subject.keyword | COMT Val¹⁵⁸Met polymorphism | - |
dc.subject.keyword | Toronto alexithymia scale | - |
dc.subject.keyword | endophenotype | - |
dc.subject.keyword | obsessive-compulsive disorder | - |
dc.contributor.alternativeName | Kang, Jee In | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | Kang, Jee In | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.citation.volume | 57 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 721 | - |
dc.citation.endPage | 727 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(3) : 721-727, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47582 | - |
dc.type.rims | ART | - |
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