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Association between the Catechol-O-Methyltransferase (COMT) Val¹⁵⁸Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder.

DC Field Value Language
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author남궁기-
dc.date.accessioned2017-02-24T11:43:04Z-
dc.date.available2017-02-24T11:43:04Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146840-
dc.description.abstractPURPOSE: Alexithymia, defined as a deficit in the ability to recognize and describe one's own feelings, may be related to the development and maintenance of obsessive-compulsive symptoms. The aim of this study was to evaluate the association between the catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism and alexithymia in patients with obsessive-compulsive disorder (OCD). MATERIALS AND METHODS: We recruited 244 patients with OCD (169 males, 75 females). Alexithymia was assessed using the 20-item Toronto Alexithymia Scale (TAS-20), and genotyping of the COMT Val¹⁵⁸Met polymorphism was evaluated. RESULTS: Patients with the COMT Val/Val genotype had significantly higher total and "difficulty identifying feelings" (DIF) subdimension scores than those with the Val/Met or Met/Met genotypes. Patients with the COMT Val/Val genotype had significantly higher "difficulty describing feelings" (DDF) subdimension scores than those with the COMT Val/Met genotype. However, there were no differences in the scores for the "externally oriented thinking" (EOT) subdimension among the three genotypes. CONCLUSION: These results indicate that the high-activity Val allele of the COMT Val¹⁵⁸Met polymorphism is associated with increased alexithymic traits in patients with OCD. The present finding suggests that alexithymia is an endophenotype of OCD that is mediated by the COMT Val¹⁵⁸Met polymorphism.-
dc.description.statementOfResponsibilityopen-
dc.format.extent721~727-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAffective Symptoms/diagnosis*-
dc.subject.MESHAffective Symptoms/genetics-
dc.subject.MESHAffective Symptoms/psychology-
dc.subject.MESHAlleles-
dc.subject.MESHCatechol O-Methyltransferase/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObsessive-Compulsive Disorder/diagnosis*-
dc.subject.MESHObsessive-Compulsive Disorder/genetics-
dc.subject.MESHObsessive-Compulsive Disorder/psychology-
dc.subject.MESHPhenotype-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHRepublic of Korea-
dc.titleAssociation between the Catechol-O-Methyltransferase (COMT) Val¹⁵⁸Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder.-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorMin Jung Koh-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorSu Young Lee-
dc.contributor.googleauthorSe Joo Kim-
dc.identifier.doi10.3349/ymj.2016.57.3.721-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA01240-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid26996573-
dc.subject.keywordAlexithymia-
dc.subject.keywordCOMT Val¹⁵⁸Met polymorphism-
dc.subject.keywordToronto alexithymia scale-
dc.subject.keywordendophenotype-
dc.subject.keywordobsessive-compulsive disorder-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.citation.volume57-
dc.citation.number3-
dc.citation.startPage721-
dc.citation.endPage727-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.57(3) : 721-727, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47582-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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