0 179

Cited 33 times in

Microfluidic Production of Uniform Microcarriers with Multicompartments through Phase Separation in Emulsion Drops

Authors
 Nam Gi Min  ;  Minhee Ku  ;  Jaemoon Yang  ;  Shin-Hyun Kim 
Citation
 CHEMISTRY OF MATERIALS, Vol.28(5) : 1430-1438, 2016 
Journal Title
 CHEMISTRY OF MATERIALS 
ISSN
 0897-4756 
Issue Date
2016
Abstract
Microfluidics has provided biodegradable microcarriers for sustained release of drugs, while allowing insignificant initial bursting. Here, we further engineer the microcarriers to have multiple compartments to release distinct drugs in a more controlled fashion. With a capillary microfluidic device, monodisperse emulsion drops containing two immiscible biocompatible polymers, one is biodegradable and the other is pH-responsive, are prepared, which undergo phase separation as the solvent in the drops is depleted. The emulsion drops finally form uniform microcarriers with distinct compartments. During the phase separation and consolidation, two model drugs with different hydrophobicity involved in the drops are spontaneously concentrated in their own compartments with higher affinity. The configuration of the microcarriers is exclusively selected from five different structures depending on the pair of polymers, pH of continuous phase, and organic solvent of emulsion drops; two of five have minimum interfacial energy, and the others are kinetically arrested. Microcarriers with each configuration provide their unique release behavior of the model drugs. These are potentially useful for choosing the release profile of multiple drugs suitable for specific diseases.
Full Text
http://pubs.acs.org/doi/abs/10.1021/acs.chemmater.5b04798
DOI
10.1021/acs.chemmater.5b04798
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Min Hee(구민희) ORCID logo https://orcid.org/0000-0002-1674-1474
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146817
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse