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Upregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas.

DC Field Value Language
dc.contributor.author김수정-
dc.contributor.author양우익-
dc.contributor.author윤선옥-
dc.contributor.author조윤아-
dc.contributor.author김은경-
dc.date.accessioned2017-02-24T11:32:48Z-
dc.date.available2017-02-24T11:32:48Z-
dc.date.issued2016-
dc.identifier.issn2383-7837-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146795-
dc.description.abstractBACKGROUND: Recent studies have revealed that the splicing factor neuro-oncological ventral antigen 1 (NOVA1) is enriched in fibroblasts and accumulated T cells of tertiary lymphoid structures. In the present study, we investigated NOVA1 expression in various subtypes of mature and immature T- and natural killer (NK)-cell lymphomas as well as in various B-cell lymphoma subtypes. METHODS: NOVA1 immunoexpression was evaluated in hyperplastic palatine tonsils (n = 20), T- and NK-cell lymphomas (n = 177), diffuse large B-cell lymphomas (n = 151), and other types of B cell lymphomas (n = 31). Nuclear staining intensity and percentage of positive tumor cells were graded. NOVA1 mRNA expression was analyzed in various lymphoma cell lines. RESULTS: Tumor cells of T- and NK-cell lymphomas showed higher expression levels of NOVA1 than did normal paracortical T cells, and 56.5% of T- and NK-cell lymphoma cases showed diffuse and strong expression. The NOVA1 expression level varied according to the subtype; it was higher in angioimmunoblastic T-cell lymphoma, anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL), and T lymphoblastic leukemia/lymphoma (T-LBL), but it was lower in ALK-positive ALCL. In almost all B-cell lymphomas, NOVA1 expression was very low or negative. NOVA1 mRNA was also expressed in Jurkat, a T-LBL cell line. CONCLUSIONS: The present findings suggest that NOVA1 upregulation may be involved in certain subtypes of T- and NK-cell lymphomas, but not in B-cell lymphomas. Upregulated NOVA1 expression seems to be a specific biological feature of activated T cells such as T- and NK-cell lymphomas.-
dc.description.statementOfResponsibilityopen-
dc.format.extent104~112-
dc.languageEnglish-
dc.publisherThe Korean Society of Pathologists-
dc.relation.isPartOfJOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleUpregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas.-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorEun Kyung Kim-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorSoo Hee Kim-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorYoon Ah Cho-
dc.contributor.googleauthorSoo Jeong Kim-
dc.identifier.doi10.4132/jptm.2016.02.08-
dc.contributor.localIdA00633-
dc.contributor.localIdA02300-
dc.contributor.localIdA02566-
dc.contributor.localIdA04683-
dc.contributor.localIdA04868-
dc.relation.journalcodeJ01680-
dc.identifier.eissn2383-7845-
dc.relation.journalsince2015~-
dc.identifier.pmid26922803-
dc.relation.journalbefore~2014 Korean Journal of Pathology-
dc.subject.keywordLymphoma, T-cell-
dc.subject.keywordNK cell lymphoma-
dc.subject.keywordNOVA1-
dc.subject.keywordSplicing factor-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.alternativeNameCho, Yoon Ah-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorCho, Yoon Ah-
dc.contributor.affiliatedAuthorKim, Eun Kyung-
dc.citation.volume50-
dc.citation.number2-
dc.citation.startPage104-
dc.citation.endPage112-
dc.identifier.bibliographicCitationJOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.50(2) : 104-112, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47537-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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