Cited 14 times in
Upregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas.
DC Field | Value | Language |
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dc.contributor.author | 김수정 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 윤선옥 | - |
dc.contributor.author | 조윤아 | - |
dc.contributor.author | 김은경 | - |
dc.date.accessioned | 2017-02-24T11:32:48Z | - |
dc.date.available | 2017-02-24T11:32:48Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2383-7837 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146795 | - |
dc.description.abstract | BACKGROUND: Recent studies have revealed that the splicing factor neuro-oncological ventral antigen 1 (NOVA1) is enriched in fibroblasts and accumulated T cells of tertiary lymphoid structures. In the present study, we investigated NOVA1 expression in various subtypes of mature and immature T- and natural killer (NK)-cell lymphomas as well as in various B-cell lymphoma subtypes. METHODS: NOVA1 immunoexpression was evaluated in hyperplastic palatine tonsils (n = 20), T- and NK-cell lymphomas (n = 177), diffuse large B-cell lymphomas (n = 151), and other types of B cell lymphomas (n = 31). Nuclear staining intensity and percentage of positive tumor cells were graded. NOVA1 mRNA expression was analyzed in various lymphoma cell lines. RESULTS: Tumor cells of T- and NK-cell lymphomas showed higher expression levels of NOVA1 than did normal paracortical T cells, and 56.5% of T- and NK-cell lymphoma cases showed diffuse and strong expression. The NOVA1 expression level varied according to the subtype; it was higher in angioimmunoblastic T-cell lymphoma, anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL), and T lymphoblastic leukemia/lymphoma (T-LBL), but it was lower in ALK-positive ALCL. In almost all B-cell lymphomas, NOVA1 expression was very low or negative. NOVA1 mRNA was also expressed in Jurkat, a T-LBL cell line. CONCLUSIONS: The present findings suggest that NOVA1 upregulation may be involved in certain subtypes of T- and NK-cell lymphomas, but not in B-cell lymphomas. Upregulated NOVA1 expression seems to be a specific biological feature of activated T cells such as T- and NK-cell lymphomas. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 104~112 | - |
dc.language | English | - |
dc.publisher | The Korean Society of Pathologists | - |
dc.relation.isPartOf | JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Upregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas. | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Eun Kyung Kim | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.contributor.googleauthor | Soo Hee Kim | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Yoon Ah Cho | - |
dc.contributor.googleauthor | Soo Jeong Kim | - |
dc.identifier.doi | 10.4132/jptm.2016.02.08 | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02566 | - |
dc.contributor.localId | A04683 | - |
dc.contributor.localId | A04868 | - |
dc.relation.journalcode | J01680 | - |
dc.identifier.eissn | 2383-7845 | - |
dc.relation.journalsince | 2015~ | - |
dc.identifier.pmid | 26922803 | - |
dc.relation.journalbefore | ~2014 Korean Journal of Pathology | - |
dc.subject.keyword | Lymphoma, T-cell | - |
dc.subject.keyword | NK cell lymphoma | - |
dc.subject.keyword | NOVA1 | - |
dc.subject.keyword | Splicing factor | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.alternativeName | Cho, Yoon Ah | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | Cho, Yoon Ah | - |
dc.contributor.affiliatedAuthor | Kim, Eun Kyung | - |
dc.citation.volume | 50 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 104 | - |
dc.citation.endPage | 112 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.50(2) : 104-112, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47537 | - |
dc.type.rims | ART | - |
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