Cited 19 times in
Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors.
DC Field | Value | Language |
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dc.contributor.author | 김동석 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김준원 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 심규원 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 한정우 | - |
dc.contributor.author | 최서희 | - |
dc.contributor.author | 최서희 | - |
dc.date.accessioned | 2017-02-24T11:25:26Z | - |
dc.date.available | 2017-02-24T11:25:26Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146763 | - |
dc.description.abstract | BACKGROUND: To identify prognostic factors and define the optimal management of patients with supratentorial primitive neuroectodermal tumors (sPNETs), we investigated treatment outcomes and explored the prognostic value of specific molecular markers. METHODS: A total of 47 consecutive patients with pathologically confirmed sPNETs between May 1985 and June 2012 were included. Immunohistochemical analysis of LIN28, OLIG2, and Rad51 expression was performed and correlated with clinical outcome. RESULTS: With a median follow-up of 70 months, 5-year overall survival (OS) and progression-free survival (PFS) was 55.5% and 40%, respectively, for all patients. Age, surgical extent, and radiotherapy were significant prognostic factors for OS and PFS. Patients who received initially planned multimodal treatment without interruption (i.e., radiotherapy and surgery (≥subtotal resection), with or without chemotherapy) showed significantly higher 5-year OS (71.2%) and PFS (63.1%). In 29 patients with available tumor specimens, tumors with high expression of either LIN28 or OLIG2 or elevated level of Rad51 were significantly associated with poorer prognosis. CONCLUSIONS: We found that multimodal treatment improved outcomes for sPNET patients, especially when radiotherapy and ≥subtotal resection were part of the treatment regimen. Furthermore, we confirmed the prognostic significance of LIN28 and OLIG2 and revealed the potential role of Rad51 in sPNETs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Basic Helix-Loop-Helix Transcription Factors/metabolism | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism | - |
dc.subject.MESH | Neuroectodermal Tumors, Primitive/metabolism | - |
dc.subject.MESH | Neuroectodermal Tumors, Primitive/pathology | - |
dc.subject.MESH | Neuroectodermal Tumors, Primitive/therapy* | - |
dc.subject.MESH | Oligodendrocyte Transcription Factor 2 | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | RNA-Binding Proteins/metabolism | - |
dc.subject.MESH | Rad51 Recombinase/metabolism | - |
dc.subject.MESH | Supratentorial Neoplasms/metabolism | - |
dc.subject.MESH | Supratentorial Neoplasms/pathology | - |
dc.subject.MESH | Supratentorial Neoplasms/therapy* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Seo Hee Choi | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Kyu-Won Shim | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | DongSeok Kim | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.identifier.doi | 10.1371/journal.pone.0153443 | - |
dc.contributor.localId | A00402 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A02187 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A04325 | - |
dc.contributor.localId | A04867 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 27074032 | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Shim, Kyu Won | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.alternativeName | Choi, Seo Hee | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Shim, Kyu Won | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Choi, Seo Hee | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e0153443 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(4) : e0153443, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47506 | - |
dc.type.rims | ART | - |
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