Cited 25 times in
Expansion of CD8(+) T cells lacking the IL-6 receptor α chain in patients with coronary artery diseases (CAD).
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 유희태 | - |
dc.date.accessioned | 2017-02-24T11:25:19Z | - |
dc.date.available | 2017-02-24T11:25:19Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146762 | - |
dc.description.abstract | BACKGROUND AND AIMS: The pathogenesis of coronary artery disease (CAD) is closely associated with chronic inflammatory processes. CD8(+) T cells are a key participant in the pathogenesis of atherosclerosis, the major cause of CAD; however, it remains unclear which CD8(+) T-cell subset is responsible. We investigated the immunological features of CD8(+) T cells expressing low and high levels of the IL-6 receptor α chain (IL-6Rα), a cytokine known to play a key role in cardiovascular diseases. METHODS: The expression of IL-6Rα on CD8(+) T cells and its association with plasma levels of soluble components of the IL-6/IL-6Rs as well as with clinical parameters were analyzed using FACS analysis and ELISA of CAD patients and age-matched healthy controls (HCs). Immunological characteristics of CD8(+) T cells expressing low and high levels of IL-6Rα (CD8(+)IL-6Rα(low or high)) were examined by in vitro culture and intracellular FACS analysis. RESULTS: CAD patients had higher frequencies of circulating CD8(+)IL-6Rα(low) effector memory (EM) T cells compared with HCs (median frequency; 74.59% vs. 60.09%, p = 0.0158). Expanded CD8(+)IL-6Rα(low) T cells positively correlated with the frequency of senescent, cytotoxic CD8(+)CD57(+) T cells (r = 0.6655, p < 0.0001) and plasma IL-6 level (r = 0.3995, p = 0.0432) in CAD patients. Loss of IL-6Rα expression on CD8(+) T cells was induced by the combination of IL-6 and IL-15 with accompanying TCR-independent proliferation (p = 0.0101). Moreover, these CD8(+)IL-6Rα(low) T cells had features of type 1 cytotoxic CD8(+) T cells. CONCLUSIONS: Our findings suggest the possible involvement of expanded CD8(+)IL-6Rα(low) EM T cells in CAD through their pro-inflammatory and highly cytotoxic capacities. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/cytology* | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/metabolism* | - |
dc.subject.MESH | Cell Separation | - |
dc.subject.MESH | Coronary Artery Disease/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Interleukin-15/metabolism | - |
dc.subject.MESH | Interleukin-6/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptors, Interleukin-6/genetics* | - |
dc.subject.MESH | Receptors, Interleukin-6/metabolism* | - |
dc.subject.MESH | T-Lymphocyte Subsets/cytology | - |
dc.subject.MESH | T-Lymphocyte Subsets/metabolism | - |
dc.title | Expansion of CD8(+) T cells lacking the IL-6 receptor α chain in patients with coronary artery diseases (CAD). | - |
dc.type | Article | - |
dc.publisher.location | Ireland | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | Yuri Hwang | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Dong-Hyun Kim | - |
dc.contributor.googleauthor | Jiyeon Jang | - |
dc.contributor.googleauthor | Hee Young Kim | - |
dc.contributor.googleauthor | Insoo Kang | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Won-Woo Lee | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2016.03.038 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A01512 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 27062409 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0021915016301290 | - |
dc.subject.keyword | CD8(+) T cells | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | IL-6 receptor α chain | - |
dc.subject.keyword | Interleukin-6 | - |
dc.subject.keyword | Type 1 cytotoxic T cells | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.citation.volume | 249 | - |
dc.citation.startPage | 44 | - |
dc.citation.endPage | 51 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.249 : 44-51, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47505 | - |
dc.type.rims | ART | - |
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