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Expansion of CD8(+) T cells lacking the IL-6 receptor α chain in patients with coronary artery diseases (CAD).

DC Field Value Language
dc.contributor.author김현창-
dc.contributor.author박성하-
dc.contributor.author유희태-
dc.date.accessioned2017-02-24T11:25:19Z-
dc.date.available2017-02-24T11:25:19Z-
dc.date.issued2016-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146762-
dc.description.abstractBACKGROUND AND AIMS: The pathogenesis of coronary artery disease (CAD) is closely associated with chronic inflammatory processes. CD8(+) T cells are a key participant in the pathogenesis of atherosclerosis, the major cause of CAD; however, it remains unclear which CD8(+) T-cell subset is responsible. We investigated the immunological features of CD8(+) T cells expressing low and high levels of the IL-6 receptor α chain (IL-6Rα), a cytokine known to play a key role in cardiovascular diseases. METHODS: The expression of IL-6Rα on CD8(+) T cells and its association with plasma levels of soluble components of the IL-6/IL-6Rs as well as with clinical parameters were analyzed using FACS analysis and ELISA of CAD patients and age-matched healthy controls (HCs). Immunological characteristics of CD8(+) T cells expressing low and high levels of IL-6Rα (CD8(+)IL-6Rα(low or high)) were examined by in vitro culture and intracellular FACS analysis. RESULTS: CAD patients had higher frequencies of circulating CD8(+)IL-6Rα(low) effector memory (EM) T cells compared with HCs (median frequency; 74.59% vs. 60.09%, p = 0.0158). Expanded CD8(+)IL-6Rα(low) T cells positively correlated with the frequency of senescent, cytotoxic CD8(+)CD57(+) T cells (r = 0.6655, p < 0.0001) and plasma IL-6 level (r = 0.3995, p = 0.0432) in CAD patients. Loss of IL-6Rα expression on CD8(+) T cells was induced by the combination of IL-6 and IL-15 with accompanying TCR-independent proliferation (p = 0.0101). Moreover, these CD8(+)IL-6Rα(low) T cells had features of type 1 cytotoxic CD8(+) T cells. CONCLUSIONS: Our findings suggest the possible involvement of expanded CD8(+)IL-6Rα(low) EM T cells in CAD through their pro-inflammatory and highly cytotoxic capacities.-
dc.description.statementOfResponsibilityrestriction-
dc.publisherElsevier-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCD8-Positive T-Lymphocytes/cytology*-
dc.subject.MESHCD8-Positive T-Lymphocytes/metabolism*-
dc.subject.MESHCell Separation-
dc.subject.MESHCoronary Artery Disease/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHInterleukin-15/metabolism-
dc.subject.MESHInterleukin-6/blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReceptors, Interleukin-6/genetics*-
dc.subject.MESHReceptors, Interleukin-6/metabolism*-
dc.subject.MESHT-Lymphocyte Subsets/cytology-
dc.subject.MESHT-Lymphocyte Subsets/metabolism-
dc.titleExpansion of CD8(+) T cells lacking the IL-6 receptor α chain in patients with coronary artery diseases (CAD).-
dc.typeArticle-
dc.publisher.locationIreland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorYuri Hwang-
dc.contributor.googleauthorHee Tae Yu-
dc.contributor.googleauthorDong-Hyun Kim-
dc.contributor.googleauthorJiyeon Jang-
dc.contributor.googleauthorHee Young Kim-
dc.contributor.googleauthorInsoo Kang-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorWon-Woo Lee-
dc.identifier.doi10.1016/j.atherosclerosis.2016.03.038-
dc.contributor.localIdA01142-
dc.contributor.localIdA01512-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.pmid27062409-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0021915016301290-
dc.subject.keywordCD8(+) T cells-
dc.subject.keywordCoronary artery disease-
dc.subject.keywordIL-6 receptor α chain-
dc.subject.keywordInterleukin-6-
dc.subject.keywordType 1 cytotoxic T cells-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.citation.volume249-
dc.citation.startPage44-
dc.citation.endPage51-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.249 : 44-51, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47505-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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