Cited 5 times in
PTEN Methylation Dependent Sinonasal Mucosal Melanoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강버들 | - |
dc.contributor.author | 노미령 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박규현 | - |
dc.contributor.author | 이상은 | - |
dc.contributor.author | 이상희 | - |
dc.date.accessioned | 2017-02-24T11:24:02Z | - |
dc.date.available | 2017-02-24T11:24:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146757 | - |
dc.description.abstract | Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 853~858 | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Bone Neoplasms/secondary | - |
dc.subject.MESH | Carcinogenesis/genetics* | - |
dc.subject.MESH | CpG Islands/genetics | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | Epigenesis, Genetic* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/secondary | - |
dc.subject.MESH | Melanoma/enzymology | - |
dc.subject.MESH | Melanoma/genetics* | - |
dc.subject.MESH | Melanoma/metabolism | - |
dc.subject.MESH | Melanoma/pathology* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | PTEN Phosphohydrolase/genetics* | - |
dc.subject.MESH | PTEN Phosphohydrolase/metabolism | - |
dc.subject.MESH | Signal Transduction | - |
dc.title | PTEN Methylation Dependent Sinonasal Mucosal Melanoma | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Sang Hee Lee | - |
dc.contributor.googleauthor | Mi Ryung Roh | - |
dc.contributor.googleauthor | Beodeul Kang | - |
dc.contributor.googleauthor | Kyu Hyun Park | - |
dc.contributor.googleauthor | Soo Hee Kim | - |
dc.contributor.googleauthor | Sang Eun Lee | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.4143/crt.2014.356 | - |
dc.contributor.localId | A00029 | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A04566 | - |
dc.contributor.localId | A02826 | - |
dc.contributor.localId | A02841 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.relation.journalsince | 2001~ | - |
dc.identifier.pmid | 25797573 | - |
dc.relation.journalbefore | ~2001 Journal of the Korean Cancer Research Association (대한암학회지) | - |
dc.subject.keyword | Methylation | - |
dc.subject.keyword | Phosphatase and tensin homolog | - |
dc.subject.keyword | Sinonasal melanoma | - |
dc.contributor.alternativeName | Kang, Beo Deul | - |
dc.contributor.alternativeName | Roh, Mi Ryung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Park, Kyu Hyun | - |
dc.contributor.alternativeName | Lee, Sang Eun | - |
dc.contributor.alternativeName | Lee, Sang Hee | - |
dc.contributor.affiliatedAuthor | Kang, Beo Deul | - |
dc.contributor.affiliatedAuthor | Roh, Mi Ryung | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Park, Kyu Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Sang Eun | - |
dc.contributor.affiliatedAuthor | Lee, Sang Hee | - |
dc.citation.volume | 48 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 853 | - |
dc.citation.endPage | 858 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.48(2) : 853-858, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47500 | - |
dc.type.rims | ART | - |
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