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PTEN Methylation Dependent Sinonasal Mucosal Melanoma

DC FieldValueLanguage
dc.contributor.author강버들-
dc.contributor.author노미령-
dc.contributor.author라선영-
dc.contributor.author박규현-
dc.contributor.author이상은-
dc.contributor.author이상희-
dc.date.accessioned2017-02-24T11:24:02Z-
dc.date.available2017-02-24T11:24:02Z-
dc.date.issued2016-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146757-
dc.description.abstractSinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.-
dc.description.statementOfResponsibilityopen-
dc.format.extent853~858-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCancer Research and Treatment-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBone Neoplasms/secondary-
dc.subject.MESHCarcinogenesis/genetics*-
dc.subject.MESHCpG Islands/genetics-
dc.subject.MESHDNA Methylation*-
dc.subject.MESHDNA Mutational Analysis-
dc.subject.MESHEpigenesis, Genetic*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/secondary-
dc.subject.MESHMelanoma/enzymology-
dc.subject.MESHMelanoma/genetics*-
dc.subject.MESHMelanoma/metabolism-
dc.subject.MESHMelanoma/pathology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation-
dc.subject.MESHPTEN Phosphohydrolase/genetics*-
dc.subject.MESHPTEN Phosphohydrolase/metabolism-
dc.subject.MESHSignal Transduction-
dc.titlePTEN Methylation Dependent Sinonasal Mucosal Melanoma-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSang Hee Lee-
dc.contributor.googleauthorMi Ryung Roh-
dc.contributor.googleauthorBeodeul Kang-
dc.contributor.googleauthorKyu Hyun Park-
dc.contributor.googleauthorSoo Hee Kim-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorSun Young Rha-
dc.identifier.doi10.4143/crt.2014.356-
dc.contributor.localIdA00029-
dc.contributor.localIdA01278-
dc.contributor.localIdA01316-
dc.contributor.localIdA04566-
dc.contributor.localIdA02826-
dc.contributor.localIdA02841-
dc.relation.journalcodeJ00453-
dc.relation.journalsince2001~-
dc.identifier.pmid25797573-
dc.relation.journalbefore~2001 Journal of the Korean Cancer Research Association (대한암학회지)-
dc.subject.keywordMethylation-
dc.subject.keywordPhosphatase and tensin homolog-
dc.subject.keywordSinonasal melanoma-
dc.contributor.alternativeNameKang, Beo Deul-
dc.contributor.alternativeNameRoh, Mi Ryung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Kyu Hyun-
dc.contributor.alternativeNameLee, Sang Eun-
dc.contributor.alternativeNameLee, Sang Hee-
dc.contributor.affiliatedAuthorKang, Beo Deul-
dc.contributor.affiliatedAuthorRoh, Mi Ryung-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorPark, Kyu Hyun-
dc.contributor.affiliatedAuthorLee, Sang Eun-
dc.contributor.affiliatedAuthorLee, Sang Hee-
dc.citation.volume48-
dc.citation.number2-
dc.citation.startPage853-
dc.citation.endPage858-
dc.identifier.bibliographicCitationCancer Research and Treatment, Vol.48(2) : 853-858, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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