0 194

Cited 13 times in

IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation

DC FieldValueLanguage
dc.contributor.author엄지원-
dc.date.accessioned2017-02-24T11:22:02Z-
dc.date.available2017-02-24T11:22:02Z-
dc.date.issued2016-
dc.identifier.issn0021-9258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146746-
dc.description.abstractGephyrin is a central scaffold protein that mediates development, function, and plasticity of mammalian inhibitory synapses by interacting with various inhibitory synaptic proteins. Here, we show that IQSEC3, a guanine nucleotide exchange factor for ARF6, directly interacts with gephyrin, an interaction that is critical for the inhibitory synapse localization of IQSEC3. Overexpression of IQSEC3 increases inhibitory, but not excitatory, synapse density in a guanine nucleotide exchange factor activity-dependent manner. Conversely, knockdown of IQSEC3 decreases size of gephyrin cluster without altering gephyrin puncta density. Collectively, these data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent10119~10130-
dc.languageEnglish-
dc.publisherAmerican Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfJOURNAL OF BIOLOGICAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCarrier Proteins*/genetics-
dc.subject.MESHCarrier Proteins*/metabolism-
dc.subject.MESHGuanine Nucleotide Exchange Factors*/genetics-
dc.subject.MESHGuanine Nucleotide Exchange Factors*/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMembrane Proteins*/genetics-
dc.subject.MESHMembrane Proteins*/metabolism-
dc.subject.MESHRats-
dc.subject.MESHSynapses*/genetics-
dc.subject.MESHSynapses*/metabolism-
dc.titleIQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Physiology-
dc.contributor.googleauthorJi Won Um-
dc.contributor.googleauthorGayoung Choii-
dc.contributor.googleauthorDongseok Park-
dc.contributor.googleauthorDongwook Kim-
dc.contributor.googleauthorSangmin Jeo-
dc.contributor.googleauthorHyeyeon Kang-
dc.contributor.googleauthorTakuma Mori-
dc.contributor.googleauthorTheofilos Papadopoulos-
dc.contributor.googleauthorTaesun Yoo-
dc.contributor.googleauthorYeunkum Lee-
dc.contributor.googleauthorEunjoon Kim-
dc.contributor.googleauthorKatsuhiko Tabuchi-
dc.contributor.googleauthorX Jaewon Ko-
dc.identifier.doi10.1074/jbc.M115.712893-
dc.contributor.localIdA02340-
dc.relation.journalcodeJ01258-
dc.identifier.eissn1083-351X-
dc.identifier.pmid27002143-
dc.identifier.urlhttp://www.jbc.org/content/291/19/10119-
dc.subject.keywordBRAG3-
dc.subject.keywordIQSEC3-
dc.subject.keywordSynARFGEF-
dc.subject.keywordgephyrin-
dc.subject.keywordinhibition mechanism-
dc.subject.keywordinhibitory synapse-
dc.subject.keywordprotein-protein interaction-
dc.subject.keywordscaffold protein-
dc.subject.keywordsynapse-
dc.subject.keywordγ-aminobutyric acid (GABA)-
dc.contributor.alternativeNameUm, Ji Won-
dc.contributor.affiliatedAuthorUm, Ji Won-
dc.citation.volume291-
dc.citation.number19-
dc.citation.startPage10119-
dc.citation.endPage10130-
dc.identifier.bibliographicCitationJOURNAL OF BIOLOGICAL CHEMISTRY, Vol.291(19) : 10119-10130, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.