Cited 10 times in
Serum γ-Glutamyl Transferase Is Inversely Associated with Bone Mineral Density Independently of Alcohol Consumption
DC Field | Value | Language |
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dc.contributor.author | 이유미 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2017-02-24T11:19:24Z | - |
dc.date.available | 2017-02-24T11:19:24Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146732 | - |
dc.description.abstract | BACKGROUND: γ-Glutamyl transferase (GGT) is a well-known marker of chronic alcohol consumption or hepatobiliary diseases. A number of studies have demonstrated that serum levels of GGT are independently associated with cardiovascular and metabolic disorders. The purpose of this study was to test if serum GGT levels are associated with bone mineral density (BMD) in Korean adults. METHODS: A total of 462 subjects (289 men and 173 women), who visited Severance Hospital for medical checkup, were included in this study. BMD was measured using dual energy X-ray absorptiometry. Cross-sectional association between serum GGT and BMD was evaluated. RESULTS: As serum GGT levels increased from the lowest tertile (tertile 1) to the highest tertile (tertile 3), BMD decreased after adjusting for confounders such as age, body mass index, amount of alcohol consumed, smoking, regular exercise, postmenopausal state (in women), hypertension, diabetes mellitus, and hypercholesterolemia. A multiple linear regression analysis showed a negative association between log-transformed serum GGT levels and BMD. In a multiple logistic regression analysis, tertile 3 of serum GGT level was associated with an increased risk for low bone mass compared to tertile 1 (odds ratio, 2.271; 95% confidence interval, 1.340 to 3.850; P=0.002). CONCLUSION: Serum GGT level was inversely associated with BMD in Korean adults. Further study is necessary to fully elucidate the mechanism of the inverse relationship. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 64~71 | - |
dc.language | English | - |
dc.publisher | Korean Endocrine Society | - |
dc.relation.isPartOf | Endocrinology and Metabolism (대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Serum γ-Glutamyl Transferase Is Inversely Associated with Bone Mineral Density Independently of Alcohol Consumption | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Han Seok Choi | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.identifier.doi | 10.3803/EnM.2016.31.1.64 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A00317 | - |
dc.relation.journalcode | J00773 | - |
dc.relation.journalsince | 2011~ | - |
dc.identifier.pmid | 26676328 | - |
dc.relation.journalbefore | ~2010 Journal of Korea Society of Endocrinology (대한내분비학회지) | - |
dc.subject.keyword | Bone density | - |
dc.subject.keyword | Gamma-glutamyltransferase | - |
dc.subject.keyword | Metabolic disorders | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.citation.volume | 31 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 64 | - |
dc.citation.endPage | 71 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism (대한내분비학회지), Vol.31(1) : 64-71, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47475 | - |
dc.type.rims | ART | - |
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