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Molecular Imaging of CD44-Overexpressing Gastric Cancer in Mice Using T2 MR Imaging

 Hwunjae Lee  ;  Seung-Hyun Yang  ;  Dan Heo  ;  Heyoung Son  ;  Seungjoo Haam  ;  Jin-Suck Suh  ;  Jaemoon Yang  ;  Yong-Min Huh 
 Journal of Nanoscience and Nanotechnology, Vol.16(1) : 196-202, 2016 
Journal Title
 Journal of Nanoscience and Nanotechnology 
Issue Date
Animals ; Contrast Media*/chemistry ; Contrast Media*/pharmacology ; Female ; Ferric Compounds*/chemistry ; Ferric Compounds*/pharmacology ; Hyaluronan Receptors/biosynthesis* ; Magnetic Resonance Imaging ; Manganese Compounds*/chemistry ; Manganese Compounds*/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Imaging/methods* ; Nanoparticles/chemistry* ; Neoplasm Proteins/biosynthesis* ; Neoplasms, Experimental*/diagnostic imaging ; Neoplasms, Experimental*/metabolism ; Radiography ; Stomach Neoplasms*/diagnostic imaging ; Stomach Neoplasms*/metabolism
Contrast Agent ; Gastric Cancer ; CD44 ; Magnetic Nanoparticles ; Magnetic Resonance Imaging
Novel diagnostic techniques have been developed in many research area using targetable contrast agents with magnetic resonance imaging (MRI) for cancer diagnosis. For cancer diagnosis, the use of MRI with biocompatible targeting moieties and manganese ferrite nanoparticles (MFNPs) is preferred. Thus, we synthesized MFNPs using a thermal decomposition method which enables sensitive T2 or T2 Turbo Spin Echo (TSE) MRI and coated them with hyaluronic acid (HA). The high targeting ability of HA-MFNPs was observed at MKN-45 cells (gastric cancer cell line) which high-expressing CD44 in contrast with MKN-28 cells which low-expressing CD44. We also prepared the gastric cancer mice model using MKN-45 cells which has the stem-like property was implanted into BALB/c nude mice. And then HA-MFNPs of the T2 contrast enhancement effects and targeting ability were investigated by in vivo MR imaging. As a result of these studies, we conclude that HA coated MFNPs can be effectively used as a novel probes for visualizing gastric cancer stem cells.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
손혜영(Son, Hye Yeong) ORCID logo https://orcid.org/0000-0001-5977-6784
양재문(Yang, Jae Moon) ORCID logo https://orcid.org/0000-0001-7365-0395
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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