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Molecular Imaging of CD44-Overexpressing Gastric Cancer in Mice Using T2 MR Imaging

Authors
 Hwunjae Lee  ;  Seung-Hyun Yang  ;  Dan Heo  ;  Heyoung Son  ;  Seungjoo Haam  ;  Jin-Suck Suh  ;  Jaemoon Yang  ;  Yong-Min Huh 
Citation
 JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Vol.16(1) : 196-202, 2016 
Journal Title
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN
 1533-4880 
Issue Date
2016
MeSH
Animals ; Contrast Media*/chemistry ; Contrast Media*/pharmacology ; Female ; Ferric Compounds*/chemistry ; Ferric Compounds*/pharmacology ; Hyaluronan Receptors/biosynthesis* ; Magnetic Resonance Imaging ; Manganese Compounds*/chemistry ; Manganese Compounds*/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Imaging/methods* ; Nanoparticles/chemistry* ; Neoplasm Proteins/biosynthesis* ; Neoplasms, Experimental*/diagnostic imaging ; Neoplasms, Experimental*/metabolism ; Radiography ; Stomach Neoplasms*/diagnostic imaging ; Stomach Neoplasms*/metabolism
Keywords
Contrast Agent ; Gastric Cancer ; CD44 ; Magnetic Nanoparticles ; Magnetic Resonance Imaging
Abstract
Novel diagnostic techniques have been developed in many research area using targetable contrast agents with magnetic resonance imaging (MRI) for cancer diagnosis. For cancer diagnosis, the use of MRI with biocompatible targeting moieties and manganese ferrite nanoparticles (MFNPs) is preferred. Thus, we synthesized MFNPs using a thermal decomposition method which enables sensitive T2 or T2 Turbo Spin Echo (TSE) MRI and coated them with hyaluronic acid (HA). The high targeting ability of HA-MFNPs was observed at MKN-45 cells (gastric cancer cell line) which high-expressing CD44 in contrast with MKN-28 cells which low-expressing CD44. We also prepared the gastric cancer mice model using MKN-45 cells which has the stem-like property was implanted into BALB/c nude mice. And then HA-MFNPs of the T2 contrast enhancement effects and targeting ability were investigated by in vivo MR imaging. As a result of these studies, we conclude that HA coated MFNPs can be effectively used as a novel probes for visualizing gastric cancer stem cells.
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Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146724
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