0 170

Cited 7 times in

Optimal assessment of lymph node status in gallbladder cancer

DC FieldValueLanguage
dc.contributor.author강창무-
dc.contributor.author김경식-
dc.contributor.author이우정-
dc.contributor.author임진홍-
dc.contributor.author정재욱-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.date.accessioned2017-02-24T11:16:22Z-
dc.date.available2017-02-24T11:16:22Z-
dc.date.issued2016-
dc.identifier.issn0748-7983-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146717-
dc.description.abstractBACKGROUND: Lymph node (LN) metastasis is an important prognostic factor in gallbladder cancer (GBCA). LN status has been adopted as a critical element of staging systems. However, the influence of total lymph node count (TLNC) remains unclear. We determined the optimal minimum TLNC and compared the prognostic significance of LN status indices in GBCA. METHODS: We retrospectively reviewed medical records of 128 patients with T2 or greater GBCA who underwent LN dissection. We analyzed overall survival (OS) and relevance of the number of metastatic LNs, ratio of metastatic LNs to retrieved LNs (LNR), and TLNC in predicting OS. RESULTS: The median OS durations were 120, 35, and 18 months in T2, T3, and T4 GBCA. Five-year OS rates were 73%, 43%, and 0% in T2, T3, and T4 GBCA. LN status did not significantly impact OS in T2 or T4 GBCA. However, all LN indices were significantly correlated with OS in T3 GBCA. Furthermore, multivariate analysis revealed that a metastatic LN count of more than four and a TLNC of more than eight were independent prognostic factors of OS in T3 GBCA. CONCLUSIONS: TLNC and the number of positive LNs may be more important prognostic factors than LNR in T3 GBCA. Additionally, accurate staging may not be achieved in cases of T3 GBCA if the total number of retrieved LNs is less than eight. Thus, to ensure proper staging, we recommend that surgeons harvest more than eight LNs in patients with T3 GBCA.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent205~210-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfEuropean Journal of Surgical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCholecystectomy-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFemale-
dc.subject.MESHGallbladder Neoplasms/pathology*-
dc.subject.MESHGallbladder Neoplasms/therapy*-
dc.subject.MESHHumans-
dc.subject.MESHLymph Node Excision*-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymph Nodes/surgery-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.titleOptimal assessment of lymph node status in gallbladder cancer-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorS.H. Kim-
dc.contributor.googleauthorJ.U. Chong-
dc.contributor.googleauthorJ.H. Lim-
dc.contributor.googleauthorG.H. Choi-
dc.contributor.googleauthorC.M. Kang-
dc.contributor.googleauthorJ.S. Choi-
dc.contributor.googleauthorW.J. Lee-
dc.contributor.googleauthorK.S. Kim-
dc.identifier.doi10.1016/j.ejso.2015.10.013-
dc.contributor.localIdA00088-
dc.contributor.localIdA00299-
dc.contributor.localIdA02993-
dc.contributor.localIdA03411-
dc.contributor.localIdA03710-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.relation.journalcodeJ00847-
dc.identifier.pmid26614023-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0748798315008367-
dc.subject.keywordGallbladder cancer-
dc.subject.keywordLymph node-
dc.subject.keywordOverall survival-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameLim, Jin Hong-
dc.contributor.alternativeNameChong, Jae Uk-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorLim, Jin Hong-
dc.contributor.affiliatedAuthorChong, Jae Uk-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.citation.volume42-
dc.citation.number2-
dc.citation.startPage205-
dc.citation.endPage210-
dc.identifier.bibliographicCitationEuropean Journal of Surgical Oncology, Vol.42(2) : 205-210, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.