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Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents

 Seo Hee Yoon  ;  Han Wool Kim  ;  Jong Gyun Ahn  ;  In Tae Kim  ;  Jong-Hyun Kim  ;  Kyoung Ae Kong  ;  Kyung-Hyo Kim 
 Journal of Korean Medical Science, Vol.31(1) : 73-79, 2016 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Adolescent ; Antibody Formation ; Female ; Hepatitis A/immunology ; Hepatitis A/prevention & control* ; Hepatitis A Antibodies/blood ; Hepatitis A Vaccines/adverse effects ; Hepatitis A Vaccines/immunology* ; Humans ; Male ; Republic of Korea ; Vaccines, Inactivated/adverse effects ; Vaccines, Inactivated/immunology ; Young Adult
Adolescent ; Antibody Formation ; Hepatitis A Vaccines ; Safety
Although the overall incidence of hepatitis A in Korea has been decreasing, adolescents remain highly vulnerable to its outbreaks. This study was conducted to compare the immunogenicity and safety of three hepatitis A vaccines in Korean adolescents. Healthy anti-hepatitis A virus seronegative subjects aged 13 to 19 yr were randomized in three equal groups to receive two doses of Avaxim™, Epaxal®, or Havrix®, 6 to 12 months apart. Seroconversion rates one month after the first dose were 98%, 95%, and 93% for Avaxim™, Epaxal®, and Havrix®, respectively. Seroconversion rates reached 100% for all vaccine groups one month after the second dose. Anti-HAV geometric mean concentrations (GMCs) were 7,207.7 mIU/mL (95% CI, 6023.1-8684.7), 1,750.5 mIU/mL (95% CI, 1362.9-2248.3), and 1,953.5 mIU/mL (95% CI, 1459.4-2614.7) after two doses of Avaxim™, Epaxal®, and Havrix® respectively. Avaxim™ was significantly more immunogenic than Epaxal® and Havrix®, whereas there were no significant differences in antibody responses between Epaxal® and Havrix®. Local and systemic solicited adverse events (AEs) were mostly of mild-to-moderate intensity and resolved within 5 days. No serious AEs were reported. In conclusion, all three vaccines are highly immunogenic and well-tolerated in Korean adolescents. (Clinical Trial Registry NCT00483470).
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Yonsei Authors
Yoon, Seo Hee(윤서희) ORCID logo https://orcid.org/0000-0002-8361-9815
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