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Cited 5 times in

Estrogen Receptor Status Predicts Late-Onset Skeletal Recurrence in Breast Cancer Patients

DC FieldValueLanguage
dc.contributor.author강숙희-
dc.contributor.author김백길-
dc.contributor.author이성환-
dc.contributor.author조남훈-
dc.contributor.author한현호-
dc.date.accessioned2017-02-24T11:11:05Z-
dc.date.available2017-02-24T11:11:05Z-
dc.date.issued2016-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146678-
dc.description.abstractEstrogen receptor-positive (ER+) breast cancer (BCa) often recurs after long latency, and is known to favor bone as a metastatic site. We hypothesized that skeletal recurrence of ER+ BCa follows a different chronological pattern from that of nonskeletal recurrence.We retrospectively evaluated 434 matched pairs of ER+ and ER- female patients who underwent surgery for clinically localized BCa between 2005 and 2009. Patient age, tumor size, lymph node involvement, and adjuvant treatment biases were adjusted by the propensity score method. We conducted competing risk analysis to determine the prognostic significance of ER expression status on the risk of overall recurrence and late recurrence (after 3 years). We also compared chronological patterns of ER+ and ER- tumor recurrence, stratified by the first metastatic site (skeletal vs nonskeletal).After 3 postoperative years, ER+ tumor had a significantly higher risk of overall distant recurrence than ER- tumor (P = 0.02). When further stratified by first site of metastasis, only late skeletal recurrence was significantly associated with ER status (P = 0.029). In multivariate analysis, ER and lymph node involvement status were significant prognostic factors for late skeletal recurrence, with adjusted hazard ratios of 5.2 (95% CI = 1.2-22.4, P = 0.025) and 5.2 (1.7-16.3, P = 0.005), respectively. For nonskeletal distant recurrence, tumor size (>2 cm) was the only significant risk factor with adjusted hazard ratio of 2.8 (1.4-5.7, P = 0.005). Annual hazard of skeletal recurrence events of ER+ tumors continued to exist up to 10 years, while annual hazard of nonskeletal recurrences decreased after peaking at 5 years. ER- tumor recurrences exhibited similar annual hazard patterns across skeletal and nonskeletal sites.ER expression and lymph node involvement status were strong predictors of BCa late-onset (>3 years) recurrences, especially in skeletal sites. Therefore, skeletal system surveillance is mandatory for long-term follow-up of this subpopulation.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHBreast Neoplasms/surgery*-
dc.subject.MESHDiagnostic Imaging-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIn Situ Hybridization, Fluorescence-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis*-
dc.subject.MESHPropensity Score-
dc.subject.MESHReceptors, Estrogen/metabolism*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Analysis-
dc.titleEstrogen Receptor Status Predicts Late-Onset Skeletal Recurrence in Breast Cancer Patients-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorHyun Ho Han-
dc.contributor.googleauthorSung Hwan Lee-
dc.contributor.googleauthorBaek Gil Kim-
dc.contributor.googleauthorJoo Hyun Lee-
dc.contributor.googleauthorSuki Kang-
dc.contributor.googleauthorNam Hoon Cho-
dc.identifier.doi10.1097/MD.0000000000002909-
dc.contributor.localIdA00044-
dc.contributor.localIdA00484-
dc.contributor.localIdA02875-
dc.contributor.localIdA03812-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid26937933-
dc.contributor.alternativeNameKang, Suki-
dc.contributor.alternativeNameKim, Baek Gil-
dc.contributor.alternativeNameLee, Sung Hwan-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.affiliatedAuthorKang, Suki-
dc.contributor.affiliatedAuthorKim, Baek Gil-
dc.contributor.affiliatedAuthorLee, Sung Hwan-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.citation.volume95-
dc.citation.number8-
dc.citation.startPage2909-
dc.identifier.bibliographicCitationMEDICINE, Vol.95(8) : 2909, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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