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Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells.

DC FieldValueLanguage
dc.contributor.author성진실-
dc.contributor.author이은정-
dc.date.accessioned2017-02-24T11:10:37Z-
dc.date.available2017-02-24T11:10:37Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146674-
dc.description.abstractRadiotherapy (RT) is a potent anti-tumor modality. However, unwanted effects including increased recurrence and metastasis that involve factors such as cytokines, which induce complex molecular mechanisms, have also been reported. In a previous study, we showed that interleukin (IL)-12 and radiotherapy combination treatment suppressed tumor growth and metastasis in a hepatoma mouse model. In this study, we investigated the mechanism underlying the IL-12 anti-tumor effect during radiotherapy. In tumor-bearing mice, irradiation decreased IL-12 expression in the tumors and spleens. However, a number of dendritic cells infiltrated into the tumors in which IL-12 expression did not decrease. To further study the underlying detailed mechanism for this decrease in IL-12, LPS-stimulated bone marrow-derived dendritic cells (BMDCs) were irradiated, and then IL-12- and IL-6-associated molecules were examined in irradiated tumors and BMDCs. Irradiation resulted in IL-12 suppression and IL-6 increase. IL-6 and signal transducer and activator of transcription 3 (STAT3) inhibitors restored the irradiation-induced IL-12 decrease via suppression of C-Rel activation. Taken together, our study suggests that irradiation-induced IL-6 can decrease IL-12 production through the inhibition of C-Rel phosphorylation by the IL-6/STAT3 signaling pathway.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0146463-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinoma, Hepatocellular/immunology-
dc.subject.MESHCarcinoma, Hepatocellular/metabolism-
dc.subject.MESHCarcinoma, Hepatocellular/radiotherapy-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDendritic Cells/immunology-
dc.subject.MESHDendritic Cells/metabolism*-
dc.subject.MESHDendritic Cells/radiation effects-
dc.subject.MESHInterleukin-12/biosynthesis*-
dc.subject.MESHInterleukin-6/physiology*-
dc.subject.MESHLipopolysaccharides/pharmacology-
dc.subject.MESHLiver Neoplasms, Experimental/immunology-
dc.subject.MESHLiver Neoplasms, Experimental/metabolism-
dc.subject.MESHLiver Neoplasms, Experimental/radiotherapy-
dc.subject.MESHMale-
dc.subject.MESHMice, Inbred C3H-
dc.subject.MESHNeoplasm Transplantation-
dc.subject.MESHProto-Oncogene Proteins c-rel/physiology*-
dc.subject.MESHSTAT3 Transcription Factor/metabolism*-
dc.subject.MESHSignal Transduction-
dc.titleRadiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells.-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorEun-Jung Lee-
dc.contributor.googleauthorSeo Jin Lee-
dc.contributor.googleauthorJi-Hye Kim-
dc.contributor.googleauthorKyoung-Jin Kim-
dc.contributor.googleauthorSeung-Hyun Yang-
dc.contributor.googleauthorKeun Yeong Jeong-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1371/journal.pone.0146463-
dc.contributor.localIdA01956-
dc.contributor.localIdA03047-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid26745884-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameLee, Eun Jung-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorLee, Eun Jung-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPagee0146463-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(1) : e0146463, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47419-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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