Cited 27 times in
Effect of Icodextrin Solution on the Preservation of Residual Renal Function in Peritoneal Dialysis Patients: A Randomized Controlled Study
DC Field | Value | Language |
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dc.contributor.author | 유태현 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2017-02-24T11:06:17Z | - |
dc.date.available | 2017-02-24T11:06:17Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146646 | - |
dc.description.abstract | Although icodextrin solution has been highlighted in the fluid management compared to glucose-based solutions, proof of a beneficial effect of icodextrin solution on residual renal function (RRF) is lacking. We conducted a multicenter prospective randomized controlled open-label trial to investigate whether icodextrin solution can preserve RRF.One hundred patients with urine volume ≥750 mL/day from 8 centers in Korea were randomly assigned to receive 1 exchange of icodextrin solution for a ≥8 hour-dwell time and 2 exchanges of 1.5% glucose-based biocompatible neutral pH solution or 1 exchange of ≥2.5% and 2 exchanges of 1.5% glucose-based biocompatible solutions. Using mixed-effects general linear models, we analyzed changes in residual glomerular filtration rate (GFR) and daily urine volume at 1 year.Forty-nine patients were assigned to the icodextrin group and 51 to the glucose solution group. During follow-up, the slope of the decline in residual GFR was -0.170 mL/min/month/1.73 m² in the icodextrin group, while it was -0.155 mL/min/month/1.73 m² in the glucose solution group (95% confidence interval [CI], -0.06 to 0.10; P = 0.701). Daily urine volume decreased faster in the glucose solution group than in the icodextrin group (-31.02 vs -11.88 mL per month; 95% CI, -35.85 to -2.44; P = 0.025). Results were consistent when we analyzed using intention-to-treat and per protocol principles. There were no differences in fluid status, peritoneal ultrafiltration, and peritoneal transport between groups during follow-up.This study clearly showed that icodextrin solution preserves residual urine volume better than glucose solution. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate/drug effects* | - |
dc.subject.MESH | Glucans/adverse effects | - |
dc.subject.MESH | Glucans/therapeutic use* | - |
dc.subject.MESH | Glucose/adverse effects | - |
dc.subject.MESH | Glucose/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Peritoneal Dialysis/methods* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Effect of Icodextrin Solution on the Preservation of Residual Renal Function in Peritoneal Dialysis Patients: A Randomized Controlled Study | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Dong-Ryeol Ryu | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Hyung Jong Kim | - |
dc.contributor.googleauthor | Ea Wha Kang | - |
dc.contributor.googleauthor | Hyunwook Kim | - |
dc.contributor.googleauthor | Jae Hyun Chang | - |
dc.contributor.googleauthor | Dong Ki Kim | - |
dc.contributor.googleauthor | Sung Jin Moon | - |
dc.contributor.googleauthor | Soo Young Yoon | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.1097/MD.0000000000002991 | - |
dc.contributor.localId | A01126 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 27043667 | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.citation.volume | 95 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 2991 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.95(13) : 2991, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47392 | - |
dc.type.rims | ART | - |
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