Cited 66 times in
Effects of dexmedetomidine on oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease undergoing lung cancer surgery: A randomised double-blinded trial
DC Field | Value | Language |
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dc.contributor.author | 김남오 | - |
dc.contributor.author | 반민지 | - |
dc.contributor.author | 오영준 | - |
dc.contributor.author | 이수현 | - |
dc.contributor.author | 이창영 | - |
dc.date.accessioned | 2017-02-24T11:06:02Z | - |
dc.date.available | 2017-02-24T11:06:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0265-0215 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146645 | - |
dc.description.abstract | BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a risk factor that increases the incidence of postoperative cardiopulmonary morbidity and mortality after lung resection. Dexmedetomidine, a selective α2-adrenoreceptor agonist, has been reported previously to attenuate intrapulmonary shunt during one-lung ventilation (OLV) and to alleviate bronchoconstriction. OBJECTIVE: The objective is to determine whether dexmedetomidine improves oxygenation and lung mechanics in patients with moderate COPD during lung cancer surgery. DESIGN: A randomised, double-blinded, placebo-controlled study. SETTING: Single university hospital. PARTICIPANTS: Fifty patients scheduled for video-assisted thoracoscopic surgery who had moderate COPD. Patients were randomly allocated to a control group or a Dex group (n = 25 each). INTERVENTIONS: In the Dex group, dexmedetomidine was given as an initial loading dose of 1.0 μg kg(-1) over 10 min followed by a maintenance dose of 0.5 μg kg(-1) h(-1) during OLV while the control group was administered a comparable volume of 0.9% saline. Data were measured at 30 min (DEX-30) and 60 min (DEX-60) after dexmedetomidine or saline administration during OLV. MAIN OUTCOME MEASURES: The primary outcome was the effect of dexmedetomidine on oxygenation. The secondary outcome was the effect of dexmedetomidine administration on postoperative pulmonary complications. RESULTS: Patients in the Dex group had a significantly higher PaO2/FIO2 ratio (27.9 ± 5.8 vs. 22.5 ± 8.4 and 28.6 ± 5.9 vs. 21.0 ± 9.9 kPa, P < 0.05), significantly lower dead space ventilation (19.2 ± 8.5 vs. 24.1 ± 8.1 and 19.6 ± 6.7 vs. 25.3 ± 7.8%, P < 0.05) and higher dynamic compliance at DEX-30 and DEX-60 (P = 0.0001 and P = 0.0184) compared with the control group. In the Dex group, the PaO2/FIO2 ratio in the postoperative period was significantly higher (P = 0.022) and the incidence of ICU admission was lower than in the control group. CONCLUSION: Dexmedetomidine administration may provide clinically relevant benefits by improving oxygenation and lung mechanics in patients with moderate COPD undergoing lung cancer surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 275~282 | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF ANAESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/administration & dosage* | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/adverse effects | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bronchodilator Agents/administration & dosage* | - |
dc.subject.MESH | Bronchodilator Agents/adverse effects | - |
dc.subject.MESH | Dexmedetomidine/administration & dosage* | - |
dc.subject.MESH | Dexmedetomidine/adverse effects | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hospitals, University | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung/drug effects* | - |
dc.subject.MESH | Lung/physiopathology | - |
dc.subject.MESH | Lung/surgery* | - |
dc.subject.MESH | Lung Neoplasms/diagnosis | - |
dc.subject.MESH | Lung Neoplasms/physiopathology | - |
dc.subject.MESH | Lung Neoplasms/surgery* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pneumonectomy*/adverse effects | - |
dc.subject.MESH | Pneumonectomy*/methods | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/diagnosis | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/drug therapy* | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/physiopathology | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Respiratory Mechanics/drug effects* | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Thoracic Surgery, Video-Assisted*/adverse effects | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effects of dexmedetomidine on oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease undergoing lung cancer surgery: A randomised double-blinded trial | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Su Hyun Lee | - |
dc.contributor.googleauthor | Namo Kim | - |
dc.contributor.googleauthor | Chang Yeong Lee | - |
dc.contributor.googleauthor | Min Gi Ban | - |
dc.contributor.googleauthor | Young Jun Oh | - |
dc.identifier.doi | 10.1097/EJA.0000000000000405 | - |
dc.contributor.localId | A00356 | - |
dc.contributor.localId | A04577 | - |
dc.contributor.localId | A02389 | - |
dc.contributor.localId | A02897 | - |
dc.contributor.localId | A03245 | - |
dc.relation.journalcode | J00807 | - |
dc.identifier.eissn | 1365-2346 | - |
dc.identifier.pmid | 26716866 | - |
dc.contributor.alternativeName | Kim, Namo | - |
dc.contributor.alternativeName | Ban, Min Gi | - |
dc.contributor.alternativeName | Oh, Young Jun | - |
dc.contributor.alternativeName | Lee, Su Hyun | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Kim, Namo | - |
dc.contributor.affiliatedAuthor | Ban, Min Gi | - |
dc.contributor.affiliatedAuthor | Oh, Young Jun | - |
dc.contributor.affiliatedAuthor | Lee, Su Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 275 | - |
dc.citation.endPage | 282 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF ANAESTHESIOLOGY, Vol.33(4) : 275-282, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47391 | - |
dc.type.rims | ART | - |
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