Cited 23 times in
A phase II study of preoperative mFOLFOX6 with short-course radiotherapy in patients with locally advanced rectal cancer and liver-only metastasis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 정민규 | - |
dc.date.accessioned | 2017-02-24T10:50:34Z | - |
dc.date.available | 2017-02-24T10:50:34Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146639 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: To evaluate the efficacy and safety of upfront mFOLFOX6 followed by short-course radiotherapy (SCRT) and surgery in patients with locally advanced rectal cancer and liver-only metastases. MATERIALS AND METHODS: This single-arm phase II study involved 32 patients. mFOLFOX6 was administered for four cycles followed by SCRT and another four cycles of mFOLFOX6. Surgery was performed 4-6 weeks after the last chemotherapy cycle. The primary endpoint was complete (R0) resection rate. Secondary endpoints were response rate, progression-free survival (PFS), overall survival (OS), and complication rates. RESULTS: Surgical resection of the rectum and liver was performed in 25 patients (78%) and R0 resection was achieved in 20 patients (63%). Local tumor downstaging was observed in 54% of patients. Median OS and PFS were 38 and 9 months, respectively. One patient discontinued treatment due to toxicity and no treatment-related deaths occurred. Patients who progressed after 4 cycles of mFOLFOX6 were less likely to receive resection. CONCLUSIONS: This regimen was safe and effective in inducing local tumor response and achieving R0 resection in this patient population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 369~374 | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | RADIOTHERAPY AND ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/secondary* | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adenocarcinoma/therapy | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/administration & dosage | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/adverse effects | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant/adverse effects | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant/methods | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Dose Fractionation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorouracil/administration & dosage | - |
dc.subject.MESH | Fluorouracil/adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leucovorin/administration & dosage | - |
dc.subject.MESH | Leucovorin/adverse effects | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Liver Neoplasms/secondary* | - |
dc.subject.MESH | Liver Neoplasms/surgery | - |
dc.subject.MESH | Liver Neoplasms/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy/adverse effects | - |
dc.subject.MESH | Neoadjuvant Therapy/methods | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Organoplatinum Compounds/administration & dosage | - |
dc.subject.MESH | Organoplatinum Compounds/adverse effects | - |
dc.subject.MESH | Rectal Neoplasms/pathology | - |
dc.subject.MESH | Rectal Neoplasms/surgery | - |
dc.subject.MESH | Rectal Neoplasms/therapy* | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | A phase II study of preoperative mFOLFOX6 with short-course radiotherapy in patients with locally advanced rectal cancer and liver-only metastasis | - |
dc.type | Article | - |
dc.publisher.location | Ireland | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Young Suk Park | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.identifier.doi | 10.1016/j.radonc.2015.11.029 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A03606 | - |
dc.relation.journalcode | J02597 | - |
dc.identifier.eissn | 1879-0887 | - |
dc.identifier.pmid | 26705682 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167814015006490 | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | Metastasis | - |
dc.subject.keyword | Rectal cancer | - |
dc.subject.keyword | Short-course radiotherapy | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.citation.volume | 118 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 369 | - |
dc.citation.endPage | 374 | - |
dc.identifier.bibliographicCitation | RADIOTHERAPY AND ONCOLOGY, Vol.118(2) : 369-374, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 48430 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.