0 313

Cited 4 times in

Duration of ovarian hormone exposure and atherosclerotic cardiovascular disease in Korean women: The Korean Heart Study

DC FieldValueLanguage
dc.contributor.author김현창-
dc.contributor.author지선하-
dc.contributor.author정금지-
dc.date.accessioned2017-02-24T08:17:59Z-
dc.date.available2017-02-24T08:17:59Z-
dc.date.issued2016-
dc.identifier.issn1072-3714-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146621-
dc.description.abstractOBJECTIVE: Although reproductive and hormonal factors, such as menarche and menopause, have been reported as independent risk factors for atherosclerotic cardiovascular disease (ASCVD), few studies have examined these factors in East Asian populations. In the Korean Heart Study, ASCVD risk related to duration of ovarian hormone exposure was examined in a cohort of 66,104 Korean women. METHODS: Study members were recruited from participants of routine health examinations at health promotion centers across South Korea in 1996-2004. Ovarian hormone exposure was defined as duration between menarche and menopause. Incidence rates for ASCVD, stroke, and ischemic heart disease were examined in relation to ovarian hormone exposure. RESULTS: The mean duration of ovarian hormone exposure at study baseline was 33.7 years, and risk for ASCVD was negatively associated with duration. Women with shorter ovarian hormone exposure (<30 y) had a higher risk of developing ASCVD (hazard ratio [HR], 1.30; 95% CI, 1.01-1.68) than women with longer ovarian hormone exposure (35-35 y). In similar comparison groups, women with ovarian hormone exposure shorter than 30 years were at increased risk for developing total stroke (HR, 1.18; 95% CI, 1.00-1.38), thrombotic stroke (HR, 1.30; 95% CI, 1.05-1.61), ischemic heart disease (HR, 1.40; 95% CI, 1.19-1.63), and acute myocardial infarction (HR, 1.73; 95% CI, 1.08-2.47). CONCLUSIONS: Our study provides further confirmation of increased cardiovascular risk with shorter reproductive years. Therefore, women with reduced lifetime ovarian hormone exposure should focus on minimizing ASCVD risk by lifestyle modifications such as smoking avoidance or increased physical activities.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent60~66-
dc.languageEnglish-
dc.publisherLippincott-Raven Publishers-
dc.relation.isPartOfMENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAsian Continental Ancestry Group/statistics & numerical data-
dc.subject.MESHAtherosclerosis/epidemiology-
dc.subject.MESHAtherosclerosis/etiology*-
dc.subject.MESHCardiovascular Diseases/epidemiology-
dc.subject.MESHCardiovascular Diseases/etiology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMenarche/physiology*-
dc.subject.MESHMenopause/physiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction/etiology-
dc.subject.MESHMyocardial Ischemia/etiology-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke/etiology-
dc.subject.MESHTime Factors*-
dc.titleDuration of ovarian hormone exposure and atherosclerotic cardiovascular disease in Korean women: The Korean Heart Study-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorKeum Ji Jung-
dc.contributor.googleauthorMee-Ran Kim-
dc.contributor.googleauthorYoung Duk Yun-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorSun Ha Jee-
dc.identifier.doi10.1097/GME.0000000000000489-
dc.contributor.localIdA01142-
dc.contributor.localIdA03965-
dc.contributor.localIdA03580-
dc.relation.journalcodeJ02219-
dc.identifier.eissn1530-0374-
dc.identifier.pmid26057825-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042192-201601000-00012&LSLINK=80&D=ovft-
dc.subject.keywordMenarche-
dc.subject.keywordMenopause-
dc.subject.keywordCardiovascular diseases-
dc.subject.keywordCohort study-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage60-
dc.citation.endPage66-
dc.identifier.bibliographicCitationMENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.23(1) : 60-66, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.