0 307

Cited 4 times in

Duration of ovarian hormone exposure and atherosclerotic cardiovascular disease in Korean women: The Korean Heart Study

Authors
 Keum Ji Jung  ;  Mee-Ran Kim  ;  Young Duk Yun  ;  Hyeon Chang Kim  ;  Sun Ha Jee 
Citation
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.23(1) : 60-66, 2016 
Journal Title
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 
ISSN
 1072-3714 
Issue Date
2016
MeSH
Asian Continental Ancestry Group/statistics & numerical data ; Atherosclerosis/epidemiology ; Atherosclerosis/etiology* ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology* ; Female ; Humans ; Incidence ; Menarche/physiology* ; Menopause/physiology* ; Middle Aged ; Myocardial Infarction/etiology ; Myocardial Ischemia/etiology ; Proportional Hazards Models ; Republic of Korea/epidemiology ; Risk Factors ; Stroke/etiology ; Time Factors*
Keywords
Menarche ; Menopause ; Cardiovascular diseases ; Cohort study
Abstract
OBJECTIVE: Although reproductive and hormonal factors, such as menarche and menopause, have been reported as independent risk factors for atherosclerotic cardiovascular disease (ASCVD), few studies have examined these factors in East Asian populations. In the Korean Heart Study, ASCVD risk related to duration of ovarian hormone exposure was examined in a cohort of 66,104 Korean women. METHODS: Study members were recruited from participants of routine health examinations at health promotion centers across South Korea in 1996-2004. Ovarian hormone exposure was defined as duration between menarche and menopause. Incidence rates for ASCVD, stroke, and ischemic heart disease were examined in relation to ovarian hormone exposure. RESULTS: The mean duration of ovarian hormone exposure at study baseline was 33.7 years, and risk for ASCVD was negatively associated with duration. Women with shorter ovarian hormone exposure (<30 y) had a higher risk of developing ASCVD (hazard ratio [HR], 1.30; 95% CI, 1.01-1.68) than women with longer ovarian hormone exposure (35-35 y). In similar comparison groups, women with ovarian hormone exposure shorter than 30 years were at increased risk for developing total stroke (HR, 1.18; 95% CI, 1.00-1.38), thrombotic stroke (HR, 1.30; 95% CI, 1.05-1.61), ischemic heart disease (HR, 1.40; 95% CI, 1.19-1.63), and acute myocardial infarction (HR, 1.73; 95% CI, 1.08-2.47). CONCLUSIONS: Our study provides further confirmation of increased cardiovascular risk with shorter reproductive years. Therefore, women with reduced lifetime ovarian hormone exposure should focus on minimizing ASCVD risk by lifestyle modifications such as smoking avoidance or increased physical activities.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042192-201601000-00012&LSLINK=80&D=ovft
DOI
10.1097/GME.0000000000000489
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146621
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse