Cited 61 times in
Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes
DC Field | Value | Language |
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dc.contributor.author | 김재우 | - |
dc.contributor.author | 김효정 | - |
dc.date.accessioned | 2017-02-24T08:15:49Z | - |
dc.date.available | 2017-02-24T08:15:49Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146603 | - |
dc.description.abstract | Caffeine has been proposed to have several beneficial effects on obesity and its related metabolic diseases; however, how caffeine affects adipocyte differentiation has not been elucidated. In this study, we demonstrated that caffeine suppressed 3T3-L1 adipocyte differentiation and inhibited the expression of CCAAT/enhancer binding protein (C/EBP)α and peroxisome proliferator-activated receptor (PPAR)γ, two main adipogenic transcription factors. Anti-adipogenic markers, such as preadipocyte secreted factor (Pref)-1 and Krüppel-like factor 2, remained to be expressed in the presence of caffeine. Furthermore, 3T3-L1 cells failed to undergo typical mitotic clonal expansion in the presence of caffeine. Investigation of hormonal signaling revealed that caffeine inhibited the activation of AKT and glycogen synthase kinase (GSK) 3 in a dose-dependent manner, but not extracellular signal-regulated kinase (ERK). Our data show that caffeine is an anti-adipogenic bioactive compound involved in the modulation of mitotic clonal expansion during adipocyte differentiation through the AKT/GSK3 pathway. [BMB Reports 2016; 49(2): 111-115]. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 111~115 | - |
dc.publisher | Korean Society for Biochemistry and Molecular Biology | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 3T3-L1 Cells | - |
dc.subject.MESH | Adipocytes/cytology | - |
dc.subject.MESH | Adipocytes/drug effects | - |
dc.subject.MESH | Adipocytes/metabolism* | - |
dc.subject.MESH | Adipogenesis/drug effects* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Caffeine/pharmacology* | - |
dc.subject.MESH | Cell Differentiation/drug effects | - |
dc.subject.MESH | Cell Differentiation/genetics | - |
dc.subject.MESH | Clone Cells | - |
dc.subject.MESH | Gene Expression Regulation/drug effects | - |
dc.subject.MESH | Glycogen Synthase Kinase 3/metabolism* | - |
dc.subject.MESH | Glycogen Synthase Kinase 3 beta | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mitosis/drug effects* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism* | - |
dc.subject.MESH | Signal Transduction/drug effects* | - |
dc.title | Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology | - |
dc.contributor.googleauthor | Hyo Jung Kim | - |
dc.contributor.googleauthor | Bo Kyung Yoon | - |
dc.contributor.googleauthor | Hyounkyoung Park | - |
dc.contributor.googleauthor | Jo Woon Seok | - |
dc.contributor.googleauthor | Hyeonjin Choi | - |
dc.contributor.googleauthor | Jung Hwan Yu | - |
dc.contributor.googleauthor | Yoonjeong Choi | - |
dc.contributor.googleauthor | Su Jin Song | - |
dc.contributor.googleauthor | Ara Kim | - |
dc.contributor.googleauthor | Jae-woo Kim | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.2.128 | - |
dc.contributor.localId | A00865 | - |
dc.contributor.localId | A01204 | - |
dc.relation.journalcode | J00348 | - |
dc.identifier.eissn | 1976-670X | - |
dc.relation.journalsince | 2008~ | - |
dc.identifier.pmid | 26350746 | - |
dc.relation.journalbefore | ~2007 Journal of Biochemistry and Molecular Biology | - |
dc.subject.keyword | Adipogenesis | - |
dc.subject.keyword | AKT | - |
dc.subject.keyword | Caffeine | - |
dc.subject.keyword | Glycogen synthase kinase | - |
dc.subject.keyword | Mitotic clonal expansion | - |
dc.contributor.alternativeName | Kim, Jae Woo | - |
dc.contributor.alternativeName | Kim, Hyo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jae Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Jung | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 115 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, Vol.49(2) : 111-115, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46412 | - |
dc.type.rims | ART | - |
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