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Biological Safety Evaluation of Polyketones as Biomaterials

Other Titles
 생체재료로서 적용을 위한 폴리케톤의 생물학적 안전성 평가 
Authors
 Mi Hee Lee  ;  Dae-Hyung Lee  ;  Hyun-Sook Baek  ;  Byeong-Ju Kwon  ;  Min-Ah Koo  ;  Min Sung Kim  ;  Gyeung Mi Seon  ;  Jong-Chul Park 
Citation
 Polymer, Vol.40(2) : 225-231, 2016 
Journal Title
 Polymer (폴리머) 
ISSN
 0379-153X 
Issue Date
2016
Keywords
polyketones ; biomaterials ; biocompatibility ; biological safety
Abstract
Biomaterials for clinical applications such as medical and implant devices require evaluation to determine their biocompatibility. This study aimed to evaluate the initial biological safety of polyketone (PK) polymers, which have potential use as biomaterials. It presents results from cytotoxicity and genotoxicity assays and tests determining the levels of skin irritation, sensitization, and acute systemic toxicity caused by PK. The PK polymers showed no cytotoxicity, genotoxicity, allergenicity, irritancy, and systemic toxicity. These results indicate that the PK polymers are potentially biological safe and could be used to replace non-degradable polymeric biomaterials.
Full Text
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE06639696
Files in This Item:
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DOI
10.7317/pk.2016.40.2.225
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Koo, Min-Ah(구민아) ORCID logo https://orcid.org/0000-0002-8671-1131
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Baek, Hyun Sook(백현숙)
Seon, Gyeung Mi(선경미) ORCID logo https://orcid.org/0000-0002-0766-1106
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146598
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