Cited 29 times in
Electrophysiological Rotor Ablation in In-Silico Modeling of Atrial Fibrillation: Comparisons with Dominant Frequency, Shannon Entropy, and Phase Singularity.
DC Field | Value | Language |
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dc.contributor.author | 박희남 | - |
dc.date.accessioned | 2017-02-24T08:13:10Z | - |
dc.date.available | 2017-02-24T08:13:10Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146586 | - |
dc.description.abstract | BACKGROUND: Although rotors have been considered among the drivers of atrial fibrillation (AF), the rotor definition is inconsistent. We evaluated the nature of rotors in 2D and 3D in- silico models of persistent AF (PeAF) by analyzing phase singularity (PS), dominant frequency (DF), Shannon entropy (ShEn), and complex fractionated atrial electrogram cycle length (CFAE-CL) and their ablation. METHODS: Mother rotor was spatiotemporally defined as stationary reentries with a meandering tip remaining within half the wavelength and lasting longer than 5 s. We generated 2D- and 3D-maps of the PS, DF, ShEn, and CFAE-CL during AF. The spatial correlations and ablation outcomes targeting each parameter were analyzed. RESULTS: 1. In the 2D PeAF model, we observed a mother rotor that matched relatively well with DF (>9 Hz, 71.0%, p<0.001), ShEn (upper 2.5%, 33.2%, p<0.001), and CFAE-CL (lower 2.5%, 23.7%, p<0.001). 2. The 3D-PeAF model also showed mother rotors that had spatial correlations with DF (>5.5 Hz, 39.7%, p<0.001), ShEn (upper 8.5%, 15.1%, p <0.001), and CFAE (lower 8.5%, 8.0%, p = 0.002). 3. In both the 2D and 3D models, virtual ablation targeting the upper 5% of the DF terminated AF within 20 s, but not the ablations based on long-lasting PS, high ShEn area, or lower CFAE-CL area. CONCLUSION: Mother rotors were observed in both 2D and 3D human AF models. Rotor locations were well represented by DF, and their virtual ablation altered wave dynamics and terminated AF. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e0149695 | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Atrial Fibrillation/physiopathology* | - |
dc.subject.MESH | Computer Simulation* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Models, Cardiovascular* | - |
dc.title | Electrophysiological Rotor Ablation in In-Silico Modeling of Atrial Fibrillation: Comparisons with Dominant Frequency, Shannon Entropy, and Phase Singularity. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Minki Hwang | - |
dc.contributor.googleauthor | Jun-Seop Song | - |
dc.contributor.googleauthor | Young-Seon Lee | - |
dc.contributor.googleauthor | Changyong Li | - |
dc.contributor.googleauthor | Eun Bo Shim | - |
dc.contributor.googleauthor | Hui Nam Pak | - |
dc.identifier.doi | 10.1371/journal.pone.0149695 | - |
dc.contributor.localId | A01776 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 26909492 | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e0149695 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(2) : e0149695, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46395 | - |
dc.type.rims | ART | - |
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