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Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation

DC FieldValueLanguage
dc.contributor.author이은직-
dc.contributor.author조윤희-
dc.date.accessioned2017-02-24T08:12:12Z-
dc.date.available2017-02-24T08:12:12Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146581-
dc.description.abstract3-hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA). From recent reports, PCA has shown vasculoprotective potency, but the effects of 3-HBA remain unclear. The aim of this study is to investigate the vasculoprotective effects of 3-HBA in endothelial cells, vascular smooth muscle cells and various animal models. We tested effects of 3-HBA in both vitro and vivo. 3-HBA showed that it prevents PDGF-induced vascular smooth muscle cells (VSMCs) migration and proliferation from MTS, BrdU assays and inhibition of AKT phosphorylation. It arrested S and G0/G1 phase of VSMC cell cycle in PI staining and it also showed inhibited expression levels of Rb1 and CD1. In human umbilical vein endothelial cells (HUVECs), 3-HBA inhibited inflammatory markers and signaling molecules (VCAM-1, ICAM-1, p-NF-κB and p-p38). For ex vivo, 3-HBA has shown dramatic effects in suppressing the sprouting from aortic ring of Spargue Dawley (SD) rats. In vivo data supported the vasculoprotective effects of 3-HBA as it inhibited angiogenesis from Matrigel Plug assay in C57BL6 mouse, prevented ADP-induced thrombus generation, increased blood circulation after formation of thrombus, and attenuated neointima formation induced by common carotid artery balloon injury of SD rats. 3-HBA, a novel therapeutic agent, has shown vasculoprotective potency in both in vitro and in vivo.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0149394-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBenzaldehydes/pharmacology*-
dc.subject.MESHCarotid Artery Injuries/metabolism-
dc.subject.MESHCatechols/pharmacology-
dc.subject.MESHCell Movement/drug effects-
dc.subject.MESHCell Proliferation/drug effects*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHG1 Phase/drug effects-
dc.subject.MESHHuman Umbilical Vein Endothelial Cells/drug effects*-
dc.subject.MESHHuman Umbilical Vein Endothelial Cells/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHInflammation/drug therapy*-
dc.subject.MESHInflammation/metabolism-
dc.subject.MESHIntercellular Adhesion Molecule-1/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMuscle, Smooth, Vascular/drug effects-
dc.subject.MESHMuscle, Smooth, Vascular/metabolism-
dc.subject.MESHMyocytes, Smooth Muscle/drug effects-
dc.subject.MESHMyocytes, Smooth Muscle/metabolism-
dc.subject.MESHNF-kappa B/metabolism-
dc.subject.MESHNeointima/drug therapy-
dc.subject.MESHNeointima/metabolism-
dc.subject.MESHPhosphorylation/drug effects-
dc.subject.MESHProto-Oncogene Proteins c-akt/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHResting Phase, Cell Cycle/drug effects-
dc.subject.MESHVascular Cell Adhesion Molecule-1/metabolism-
dc.titleVasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorByung Soo Kong-
dc.contributor.googleauthorSoo Jung Im-
dc.contributor.googleauthorYang Jong Lee-
dc.contributor.googleauthorYoon Hee Cho-
dc.contributor.googleauthorYu Ri Do-
dc.contributor.googleauthorJung Woo Byun-
dc.contributor.googleauthorCheol Ryong Ku-
dc.contributor.googleauthorEun Jig Lee-
dc.identifier.doi10.1371/journal.pone.0149394-
dc.contributor.localIdA03050-
dc.contributor.localIdA03878-
dc.contributor.localIdA00201-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27002821-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameCho, Yoon Hee-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorCho, Yoon Hee-
dc.contributor.affiliatedAuthorKu, Cheol Ryong-
dc.citation.volume11-
dc.citation.number3-
dc.citation.startPagee0149394-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(3) : e0149394, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Endocrinology (내분비연구소) > 1. Journal Papers

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