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Low P-wave amplitude (<0.1 mV) in lead I is associated with displaced inter-atrial conduction and clinical recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation.

DC FieldValueLanguage
dc.contributor.author박준범-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.date.accessioned2017-02-24T07:49:52Z-
dc.date.available2017-02-24T07:49:52Z-
dc.date.issued2016-
dc.identifier.issn1099-5129-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146531-
dc.description.abstractAIMS: We hypothesized that P-wave amplitude in lead I is related to left atrial (LA) remodelling and inter-atrial conduction pattern, and has a predictive value for recurrence after radiofrequency catheter ablation (RFCA) among patients with paroxysmal atrial fibrillation (PAF). METHODS AND RESULTS: A total of 525 consecutive patients with PAF (76% male, 56 ± 12 years old) who underwent RFCA were included. We compared pre-procedural sinus rhythm electrocardiograms without antiarrhythmic drug effect with LA volume (CT), LA voltage (NavX), the earliest activation site (EAS) conduction pattern of LA, and clinical recurrence rate. P-wave amplitude in lead I was significantly lower in patients with recurrence than in those that remained in sinus rhythm (P < 0.001) during 21 ± 10-month follow-up. P-wave amplitude in lead I was linearly correlated with LA voltage (β = 2.52, 95% CI 0.606-4.425, P = 0.010), LA conduction velocity (β = 1.91, 95% CI 0.941-2.876, P < 0.001), and low septal displacement of EAS (β = -1.67, 95% CI -2.352 to -0.996, P < 0.001). P-wave amplitudes <0.1 mV in lead I were independently associated with clinical recurrence of AF on multivariate Cox regression analysis (adjusted HR 2.163, 95% CI 1.307-3.581, P = 0.003). The integrated area under the curves was 0.705 (95% CI 0.655-0.755). CONCLUSION: Low P-wave amplitude (<0.1 mV) in lead I is related to LA remodelling and displaced inter-atrial conduction pattern to low septum, and independently predicts clinical recurrence after RFCA in patients with PAF.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent384~391-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfEUROPACE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAction Potentials-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHArea Under Curve-
dc.subject.MESHAtrial Fibrillation/diagnosis-
dc.subject.MESHAtrial Fibrillation/physiopathology-
dc.subject.MESHAtrial Fibrillation/surgery*-
dc.subject.MESHCatheter Ablation/adverse effects*-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHElectrocardiography/instrumentation*-
dc.subject.MESHElectrophysiologic Techniques, Cardiac-
dc.subject.MESHFemale-
dc.subject.MESHHeart Conduction System/physiopathology-
dc.subject.MESHHeart Conduction System/surgery*-
dc.subject.MESHHeart Rate*-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHROC Curve-
dc.subject.MESHRecurrence-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleLow P-wave amplitude (<0.1 mV) in lead I is associated with displaced inter-atrial conduction and clinical recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJin-Kyu Park-
dc.contributor.googleauthorJunbeom Park-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1093/europace/euv028-
dc.contributor.localIdA01670-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ00801-
dc.identifier.eissn1532-2092-
dc.identifier.pmid25969437-
dc.identifier.urlhttp://europace.oxfordjournals.org/content/18/3/384-
dc.subject.keywordCatheter ablation-
dc.subject.keywordInter-atrial conduction-
dc.subject.keywordP-wave-
dc.subject.keywordParoxysmal atrial fibrillation-
dc.subject.keywordRecurrence-
dc.contributor.alternativeNamePark, Jun Beom-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.affiliatedAuthorPark, Jun Beom-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.citation.volume18-
dc.citation.number3-
dc.citation.startPage384-
dc.citation.endPage391-
dc.identifier.bibliographicCitationEUROPACE, Vol.18(3) : 384-391, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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