Cited 11 times in
Effects of Dexmedetomidine on Changes in Heart Rate Variability and Hemodynamics During Tracheal Intubation.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김신형 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 신서경 | - |
dc.contributor.author | 양시준 | - |
dc.contributor.author | 오영준 | - |
dc.contributor.author | 조진선 | - |
dc.date.accessioned | 2017-02-24T07:49:32Z | - |
dc.date.available | 2017-02-24T07:49:32Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1075-2765 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146530 | - |
dc.description.abstract | Sympathetic hyperactivation during tracheal intubation prolongs the QT interval and increases the risk of arrhythmias. We investigated if dexmedetomidine pretreatment affected autonomic nervous system balance and QT intervals during intubation. Sixty-six patients were randomized to receive 1.0 μg/kg fentanyl (group F, n = 22), 0.5 μg/kg dexmedetomidine (group D0.5, n = 22), or 1.0 μg/kg dexmedetomidine (group D1.0, n = 22) before induction. Autonomic nervous system balance was assessed by the ratio of low-frequency/high-frequency (LF/HF) power for heart rate variability at baseline (T0), before intubation (T1), and after intubation (T2). QT intervals were corrected by the Bazett's formula (QTc) and compared at baseline, before intubation, and 1, 2, and 3 minutes after intubation. The LF/HF ratio was higher after intubation compared with that at T0 in group F (P < 0.001). There were no significant changes in groups D0.5 and D1.0. The LF/HF ratio was significantly higher in group F compared with those in groups D0.5 and D1.0 after intubation (7.9 vs. 2.1 and 2.5; P < 0.001). The heart rate was increased for 3 minutes after intubation in group F, whereas only for 1 minute after intubation in groups D0.5 and D1.0, compared with that at baseline. More patients in group F had QTc greater than 440 ms compared with that in group D0.5 or D1.0 (8 vs. 1 and 2; P = 0.005) at 1 minute after intubation. In contrast to 1.0 μg/kg fentanyl, pretreatment with 0.5 or 1.0 μg/kg dexmedetomidine suppressed sympathetic hyperactivity and attenuated QTc prolongation during intubation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | e369~e376 | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/pharmacology* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Dexmedetomidine/pharmacology* | - |
dc.subject.MESH | Electrocardiography/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Rate/drug effects* | - |
dc.subject.MESH | Hemodynamics/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intubation, Intratracheal* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Sympathetic Nervous System/physiology | - |
dc.title | Effects of Dexmedetomidine on Changes in Heart Rate Variability and Hemodynamics During Tracheal Intubation. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Jin Sun Cho | - |
dc.contributor.googleauthor | Shin Hyung Kim | - |
dc.contributor.googleauthor | Seokyung Shin | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | Shi Joon Yang | - |
dc.contributor.googleauthor | Young Jun Oh | - |
dc.identifier.doi | 10.1097/MJT.0000000000000074 | - |
dc.contributor.localId | A00676 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02109 | - |
dc.contributor.localId | A04602 | - |
dc.contributor.localId | A02389 | - |
dc.contributor.localId | A03914 | - |
dc.relation.journalcode | J02842 | - |
dc.identifier.eissn | 1536-3686 | - |
dc.identifier.pmid | 24832388 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00045391-201603000-00009&LSLINK=80&D=ovft | - |
dc.subject.keyword | dexmedetomidine | - |
dc.subject.keyword | fentanyl | - |
dc.subject.keyword | heart rate variability | - |
dc.subject.keyword | intubation | - |
dc.subject.keyword | intratracheal | - |
dc.subject.keyword | QT interval | - |
dc.contributor.alternativeName | Kim, Shin Hyung | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Shin, Seo Kyung | - |
dc.contributor.alternativeName | Yang, Shi Joon | - |
dc.contributor.alternativeName | Oh, Young Jun | - |
dc.contributor.alternativeName | Cho, Jin Sun | - |
dc.contributor.affiliatedAuthor | Kim, Shin Hyung | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Shin, Seo Kyung | - |
dc.contributor.affiliatedAuthor | Yang, Shi Joon | - |
dc.contributor.affiliatedAuthor | Oh, Young Jun | - |
dc.contributor.affiliatedAuthor | Cho, Jin Sun | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 369 | - |
dc.citation.endPage | 376 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF THERAPEUTICS, Vol.23(2) : 369-376, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 45161 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.