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Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair

DC FieldValueLanguage
dc.contributor.author강석민-
dc.contributor.author김신영-
dc.contributor.author김현옥-
dc.contributor.author유경종-
dc.contributor.author윤영섭-
dc.contributor.author장양수-
dc.date.accessioned2017-02-24T07:44:53Z-
dc.date.available2017-02-24T07:44:53Z-
dc.date.issued2016-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146511-
dc.description.abstractBACKGROUND: This study sought to systematically investigate the derivation of late outgrowth endothelial progenitor cells (late EPC) and mesenchymal stem cells (MSC) from umbilical cord blood (UCB) and to examine their therapeutic effects on myocardial infarction (MI). METHODS: The expression of angiogenic genes was determined by qRT-PCR. Myocardial infarction (MI) was induced in rats, and cells were directly transplanted into the border regions of ischemic heart tissue. RESULTS: Culture of UCB mononuclear cells yielded two distinct types of cells by morphology after 2 weeks in the same culture conditions. These cells were identified as late EPC and MSC, and each was intramyocardially injected into rat hearts after induction of MI. Echocardiography and histologic analyses demonstrated that both EPC and MSC improved cardiac function and enhanced vascularization, although fibrosis was reduced only in the EPC transplanted hearts. Different paracrine factors were enriched in EPC and MSC. However, once injected into the hearts, they induced similar types of paracrine factors in the heart. Transplanted EPC or MSC were mostly localized at the perivascular areas. This study demonstrated that EPC and MSC can be simultaneously derived from UCB under the same initial culture conditions, and that common paracrine factors are involved in the repair of MI. CONCLUSION: Late EPC and MSC are effective for infarct repair, apparently mediated through common humoral mechanisms.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent498~507-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfInternational Journal of Cardiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHEndothelial Progenitor Cells/transplantation*-
dc.subject.MESHHuman Umbilical Vein Endothelial Cells*/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMesenchymal Stem Cell Transplantation*/methods-
dc.subject.MESHMyocardial Infarction/therapy*-
dc.subject.MESHRats-
dc.subject.MESHRats, Nude-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHWound Healing-
dc.titleTherapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSung-Whan Kim-
dc.contributor.googleauthorHong Lian Jin-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSinyoung Kim-
dc.contributor.googleauthorKyung-Jong Yoo-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorHyun Ok Kim-
dc.contributor.googleauthorYoung-sup Yoon-
dc.identifier.doi10.1016/j.ijcard.2015.10.110-
dc.contributor.localIdA00037-
dc.contributor.localIdA00675-
dc.contributor.localIdA01122-
dc.contributor.localIdA02453-
dc.contributor.localIdA02579-
dc.contributor.localIdA03448-
dc.relation.journalcodeJ01093-
dc.identifier.pmid26551883-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S016752731530680X-
dc.subject.keywordAcute myocardial infarction-
dc.subject.keywordAngiogenesis-
dc.subject.keywordLate outgrowing endothelial progenitor cells-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordUmbilical cord blood-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameKim, Sin Young-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.alternativeNameYoo, Kyung Jong-
dc.contributor.alternativeNameYoon, Young Sup-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorKim, Sin Young-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.contributor.affiliatedAuthorYoo, Kyung Jong-
dc.contributor.affiliatedAuthorYoon, Young Sup-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.citation.volume203-
dc.citation.startPage498-
dc.citation.endPage507-
dc.identifier.bibliographicCitationInternational Journal of Cardiology, Vol.203 : 498-507, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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