Cited 22 times in
Supplementation with Angelica keiskei inhibits expression of inflammatory mediators in the gastric mucosa of Helicobacter pylori-infected mice
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.date.accessioned | 2017-02-24T07:44:18Z | - |
dc.date.available | 2017-02-24T07:44:18Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146508 | - |
dc.description.abstract | Oxidative stress is involved in the pathogenesis of Helicobacter pylori-associated gastric ulceration and carcinogenesis. The oxidant-sensitive transcription factor, nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), regulates expression of inflammatory mediators such as interferon γ (IFN-γ), cyclooxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS). These inflammatory mediators increased in gastric mucosal tissues from patients infected with H pylori. Angelica keiskei (AK), a green leafy vegetable, is rich in carotenoids and flavonoids and shows antioxidant and anti-inflammatory activities. Therefore, we hypothesized that AK may protect the gastric mucosa of H pylori-infected mice against inflammation. We determined lipid peroxide abundance, myeloperoxidase activity, expression levels of inflammatory mediators (IFN-γ, COX-2, and iNOS), NF-κB-DNA binding activity, and histologic changes in gastric mucosal tissues. The antioxidant N-acetylcysteine served as the positive control treatment. Supplementation with AK suppressed increases in lipid peroxide abundance, myeloperoxidase activity, induction of inflammatory mediators (IFN-γ, COX-2, and iNOS), activation of NF-κB, and degradation of nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor α in gastric mucosal tissue from H pylori-infected mice. Inhibition of H pylori-induced alterations by AK was similar to that by N-acetylcysteine. Taken together, these results suggest that supplementation with AK may prevent H pylori-induced gastric inflammation by inhibiting NF-κB-mediated induction of inflammatory mediators in the gastric mucosa of patients infected with H pylori. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 488~497 | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Angelica/chemistry* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents | - |
dc.subject.MESH | Antioxidants | - |
dc.subject.MESH | DNA/metabolism | - |
dc.subject.MESH | Diet | - |
dc.subject.MESH | Gastric Mucosa/chemistry* | - |
dc.subject.MESH | Gastric Mucosa/drug effects | - |
dc.subject.MESH | Gastric Mucosa/microbiology | - |
dc.subject.MESH | Helicobacter Infections/prevention & control* | - |
dc.subject.MESH | Helicobacter pylori*/genetics | - |
dc.subject.MESH | Lipid Peroxides/analysis | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | NF-KappaB Inhibitor alpha/analysis | - |
dc.subject.MESH | NF-kappa B/antagonists & inhibitors | - |
dc.subject.MESH | NF-kappa B/drug effects | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Peroxidase/metabolism | - |
dc.subject.MESH | Phytotherapy | - |
dc.subject.MESH | Plant Extracts/administration & dosage* | - |
dc.subject.MESH | RNA, Bacterial/analysis | - |
dc.subject.MESH | RNA, Ribosomal, 16S/analysis | - |
dc.title | Supplementation with Angelica keiskei inhibits expression of inflammatory mediators in the gastric mucosa of Helicobacter pylori-infected mice | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Aryoung Kim | - |
dc.contributor.googleauthor | Joo Weon Lim | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Hyeyoung Kim | - |
dc.identifier.doi | 10.1016/j.nutres.2015.12.017 | - |
dc.contributor.localId | A01183 | - |
dc.relation.journalcode | J02401 | - |
dc.identifier.eissn | 1879-0739 | - |
dc.identifier.pmid | 27101766 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0271531716000038 | - |
dc.subject.keyword | Angelica keiskei | - |
dc.subject.keyword | Gastric mucosa | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.subject.keyword | Inflammatory mediators | - |
dc.subject.keyword | Mice | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 488 | - |
dc.citation.endPage | 497 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, Vol.36(5) : 488-497, 2016 | - |
dc.date.modified | 2017-02-24 | - |
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