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Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis.

Authors
 Hyung-Ju Cho  ;  Hyun Jin Min  ;  Hyo Jin Chung  ;  Do-Yang Park  ;  Sang Yeob Seong  ;  Joo-Heon Yoon  ;  Jeung-Gweon Lee  ;  Chang-Hoon Kim 
Citation
 LARYNGOSCOPE, Vol.126(4) : 791-795, 2016 
Journal Title
 LARYNGOSCOPE 
ISSN
 0023-852X 
Issue Date
2016
MeSH
Child ; Chronic Disease ; Humans ; Hypochlorous Acid/administration & dosage* ; Nasal Lavage* ; Prospective Studies ; Sinusitis/therapy* ; Treatment Outcome
Keywords
Nasal irrigation ; hypochlorous chloride ; pediatric ; sinusitis
Abstract
OBJECTIVES/HYPOTHESIS: We aimed to evaluate the effectiveness of low-concentration hypochlorous acid (HOCl) nasal irrigation compared to isotonic normal saline for pediatric chronic rhinosinusitis. STUDY DESIGN: This was a randomized, prospective, active-controlled study. METHODS: This study investigated the effectiveness of 4 weeks of low-concentration hypochlorous irrigation by analyzing five categorized subjective symptoms and x-ray findings in pediatric patients with rhinosinusitis. Thirty-seven patients were enrolled, and 26 patients successfully completed the study. RESULTS: Total symptom scores significantly improved with both HOCl and normal saline nasal irrigation, but there was no difference between the two groups. X-ray scores also improved in both groups; improvement was much greater in the HOCl group than the placebo group. CONCLUSIONS: Nasal irrigation with HOCl is an effective adjuvant treatment compared to isotonic normal saline for pediatric sinusitis. LEVEL OF EVIDENCE: 1b.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/lary.25605/abstract
DOI
10.1002/lary.25605
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Yoon, Joo Heon(윤주헌)
Chung, Hyo Jin(정효진)
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146506
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