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A potential therapeutic effect of Saikosaponin C as a novel dual-target anti-Alzheimer agent.

Authors
 Tae Ho Lee  ;  Sungha Park  ;  Mi-Hyeon You  ;  Ji-Hong Lim  ;  Sang-Hyun Min  ;  Byeong Mo Kim 
Citation
 JOURNAL OF NEUROCHEMISTRY, Vol.136(6) : 1232-1245, 2016 
Journal Title
 JOURNAL OF NEUROCHEMISTRY 
ISSN
 0022-3042 
Issue Date
2016
Keywords
Alzheimer's disease (AD) ; Amyloid beta (Aβ) ; Microtubule (MT) ; Neurite outgrowth ; Neurodegenerative diseases ; Saikosaponin C (SSc) ; Tau ; Therapeutic tool
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the risk of developing it increases with advancing age. In this study, we investigated the protective effects of saikosaponin C (SSc), one of the main bioactive components produced by the traditional Chinese herb, radix bupleuri, the root of Bupleurum falcatum, against AD in various neuronal models. Interestingly, we found that SSc has dual effects on AD by targeting amyloid beta (Aβ) and tau, two key proteins in AD. SSc significantly suppressed the release of both Aβ peptides 1-40 and 1-42 into cell culture supernatants, though it does not affect BACE1 activity and expression. SSc also inhibited abnormal tau phosphorylation at multiple AD-related residues. Moreover, SSc seems to have beneficial effects on cellular tau function; it accelerated nerve growth factor (NGF)-mediated neurite outgrowth and increased the assembly of microtubules (MT). In addition, SSc increased synaptic marker proteins such as synaptophysin and PSD-95. Considering its various biological activities, our results suggest that SSc might be a novel therapeutic tool for treating human AD and other neurodegenerative diseases. This article is protected by copyright. All rights reserved.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jnc.13515/abstract
DOI
10.1111/jnc.13515
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Byeong Mo(김병모) ORCID logo https://orcid.org/0000-0002-0582-3132
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146482
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