Cited 14 times in
In Vitro Synergistic Effects of Antimicrobial Combinations on Extensively Drug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Isolates
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2017-02-24T07:39:49Z | - |
dc.date.available | 2017-02-24T07:39:49Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146478 | - |
dc.description.abstract | BACKGROUND: Extensively drug-resistant (XDR) Pseudomonas aeruginosa and Acinetobacter baumannii are a threat to hospitalized patients. We evaluated the effects of antimicrobial combinations on XDR P. aeruginosa and A. baumannii isolates. METHODS: P. aeruginosa and A. baumannii isolates, which were resistant to all antibiotics except colistin (CL), were collected from eight hospitals in Korea. Genes encoding metallo-β-lactamases (MBLs) and OXA carbapenemases were detected by PCR in eight P. aeruginosa and 30 A. baumannii isolates. In vitro synergy of antimicrobial combinations was tested by using the checkerboard method. RESULTS: Minimum inhibitory concentrations of β-lactams, aminoglycosides, and fluoroquinolones were very high, while that of CL was low for majority of XDR P. aeruginosa and A. baumannii isolates. Antimicrobial combinations including Imipenem (IPM)-CL, ceftazidime (CAZ)-CL, and rifampin (RIF)-CL exerted only additive/indifferent effects on majority of XDR P. aeruginosa isolates. Proportions of XDR A. baumannii isolates that showed synergistic and additive/indifferent inhibition after treatment with antimicrobial combinations used are as follows: IPM-ampicillin-sulbactam (AMS), 17% and 80% isolates, respectively; IPM-rifampin (RIF), 13% and 81% isolates, respectively; IPM-CL, 13% and 87% isolates, respectively; and RIF-COL, 20% and 73% isolates, respectively. Significant proportion (19%) of XDR P. aeruginosa isolates produced MBLs, and majority (82%) of A. baumannii isolates produced either MBLs or OXA-23. CONCLUSIONS: Our results suggest that combinations of IPM-AMS, IPM-RIF, IPM-CL, and RIF-CL are more useful than individual drugs for treating 13-20% of XDR A. baumannii infections. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 138~144 | - |
dc.language | English | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acinetobacter baumannii/drug effects* | - |
dc.subject.MESH | Acinetobacter baumannii/genetics | - |
dc.subject.MESH | Acinetobacter baumannii/isolation & purification | - |
dc.subject.MESH | Aminoglycosides/pharmacology | - |
dc.subject.MESH | Anti-Infective Agents/pharmacology* | - |
dc.subject.MESH | Bacterial Proteins/genetics | - |
dc.subject.MESH | Bacterial Proteins/metabolism | - |
dc.subject.MESH | Drug Resistance, Multiple, Bacterial/drug effects* | - |
dc.subject.MESH | Drug Synergism | - |
dc.subject.MESH | Fluoroquinolones/pharmacology | - |
dc.subject.MESH | Imipenem/pharmacology | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Pseudomonas aeruginosa/drug effects* | - |
dc.subject.MESH | Pseudomonas aeruginosa/genetics | - |
dc.subject.MESH | Pseudomonas aeruginosa/isolation & purification | - |
dc.subject.MESH | beta-Lactamases/genetics | - |
dc.subject.MESH | beta-Lactamases/metabolism | - |
dc.title | In Vitro Synergistic Effects of Antimicrobial Combinations on Extensively Drug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Isolates | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Kyung Ho Roh | - |
dc.contributor.googleauthor | Seong Geun Hong | - |
dc.contributor.googleauthor | Hee Bong Shin | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Wonkeun Song | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.identifier.doi | 10.3343/alm.2016.36.2.138 | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.relation.journalsince | 2012~ | - |
dc.identifier.pmid | 26709261 | - |
dc.relation.journalbefore | ~2011 Korean Journal of Laboratory Medicine (대한진단검사의학회지) | - |
dc.subject.keyword | Acinetobacter baumannii | - |
dc.subject.keyword | Combination chemotherapy | - |
dc.subject.keyword | In vitro synergy | - |
dc.subject.keyword | Pseudomonas aeruginosa | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.citation.volume | 36 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 138 | - |
dc.citation.endPage | 144 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.36(2) : 138-144, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 45122 | - |
dc.type.rims | ART | - |
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