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A Comparison of Gastrointestinal Toxicities between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Pancreatic Cancer.

DC Field Value Language
dc.contributor.author박승우-
dc.contributor.author송시영-
dc.contributor.author윤홍인-
dc.contributor.author정문재-
dc.contributor.author박정엽-
dc.contributor.author방승민-
dc.contributor.author성진실-
dc.date.accessioned2017-02-24T07:38:58Z-
dc.date.available2017-02-24T07:38:58Z-
dc.date.issued2016-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146475-
dc.description.abstractBACKGROUND/AIMS: Concurrent chemoradiotherapy (CCRT) is considered the treatment option for locally advanced pancreatic cancer, but accompanying gastrointestinal toxicities are the most common complication. With the introduction of three-dimensional conformal radiotherapy (3-D CRT) and intensity-modulated radiotherapy (IMRT), CCRT-related adverse events are expected to diminish. Here, we evaluated the benefits of radiation modalities by comparing gastrointestinal toxicities between 3-D CRT and IMRT. METHODS: Patients who received CCRT between July 2010 and June 2012 in Severance Hospital, Yonsei University College of Medicine, were enrolled prospectively. The patients underwent upper endoscopy before and 1 month after CCRT. RESULTS: A total of 84 patients were enrolled during the study period. The radiotherapy modalities delivered included 3D-CRT (n=40) and IMRT (n=44). The median follow-up period from the start of CCRT was 10.6 months (range, 3.8 to 29.9 months). The symptoms of dyspepsia, nausea/vomiting, and diarrhea did not differ between the groups. Upper endoscopy revealed significantly more gastroduodenal ulcers in the 3-D CRT group (p=0.003). The modality of radiotherapy (3D-CRT; odds ratio [OR], 11.67; p=0.011) and tumor location (body of pancreas; OR, 11.06; p=0.009) were risk factors for gastrointestinal toxicities. CONCLUSIONS: IMRT is associated with significantly fewer gastroduodenal injuries among patients treated with CCRT for pancreatic cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent303~309-
dc.languageEnglish-
dc.publisherEditorial Office of Gut and Liver-
dc.relation.isPartOfGUT AND LIVER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGastrointestinal Diseases/etiology*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPancreatic Neoplasms/radiotherapy*-
dc.subject.MESHProspective Studies-
dc.subject.MESHRadiation Injuries/complications*-
dc.subject.MESHRadiotherapy, Conformal/adverse effects*-
dc.subject.MESHRadiotherapy, Intensity-Modulated/adverse effects*-
dc.subject.MESHRisk Factors-
dc.titleA Comparison of Gastrointestinal Toxicities between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Pancreatic Cancer.-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorKyong Joo Lee-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorMoon Jae Chung-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorSeungmin Bang-
dc.contributor.googleauthorSeung-woo Park-
dc.contributor.googleauthorJin Sil Seong-
dc.contributor.googleauthorSi Young Song-
dc.identifier.doi10.5009/gnl15186-
dc.contributor.localIdA01551-
dc.contributor.localIdA02035-
dc.contributor.localIdA04777-
dc.contributor.localIdA03602-
dc.contributor.localIdA01647-
dc.contributor.localIdA01786-
dc.contributor.localIdA01956-
dc.relation.journalcodeJ00954-
dc.identifier.eissn2005-1212-
dc.identifier.pmid26470767-
dc.subject.keywordChemoradiotherapy-
dc.subject.keywordEndoscopy-
dc.subject.keywordGastrointestinal toxicities-
dc.subject.keywordPancreatic neoplasms-
dc.subject.keywordRadiotherapy, intensity-modulated-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameYoon, Hong In-
dc.contributor.alternativeNameChung, Moon Jae-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorYoon, Hong In-
dc.contributor.affiliatedAuthorChung, Moon Jae-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.citation.volume10-
dc.citation.number2-
dc.citation.startPage303-
dc.citation.endPage309-
dc.identifier.bibliographicCitationGUT AND LIVER, Vol.10(2) : 303-309, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid45119-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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