Cited 13 times in
A Comparison of Gastrointestinal Toxicities between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Pancreatic Cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박승우 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 정문재 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 성진실 | - |
dc.date.accessioned | 2017-02-24T07:38:58Z | - |
dc.date.available | 2017-02-24T07:38:58Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146475 | - |
dc.description.abstract | BACKGROUND/AIMS: Concurrent chemoradiotherapy (CCRT) is considered the treatment option for locally advanced pancreatic cancer, but accompanying gastrointestinal toxicities are the most common complication. With the introduction of three-dimensional conformal radiotherapy (3-D CRT) and intensity-modulated radiotherapy (IMRT), CCRT-related adverse events are expected to diminish. Here, we evaluated the benefits of radiation modalities by comparing gastrointestinal toxicities between 3-D CRT and IMRT. METHODS: Patients who received CCRT between July 2010 and June 2012 in Severance Hospital, Yonsei University College of Medicine, were enrolled prospectively. The patients underwent upper endoscopy before and 1 month after CCRT. RESULTS: A total of 84 patients were enrolled during the study period. The radiotherapy modalities delivered included 3D-CRT (n=40) and IMRT (n=44). The median follow-up period from the start of CCRT was 10.6 months (range, 3.8 to 29.9 months). The symptoms of dyspepsia, nausea/vomiting, and diarrhea did not differ between the groups. Upper endoscopy revealed significantly more gastroduodenal ulcers in the 3-D CRT group (p=0.003). The modality of radiotherapy (3D-CRT; odds ratio [OR], 11.67; p=0.011) and tumor location (body of pancreas; OR, 11.06; p=0.009) were risk factors for gastrointestinal toxicities. CONCLUSIONS: IMRT is associated with significantly fewer gastroduodenal injuries among patients treated with CCRT for pancreatic cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 303~309 | - |
dc.language | English | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gastrointestinal Diseases/etiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pancreatic Neoplasms/radiotherapy* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Radiation Injuries/complications* | - |
dc.subject.MESH | Radiotherapy, Conformal/adverse effects* | - |
dc.subject.MESH | Radiotherapy, Intensity-Modulated/adverse effects* | - |
dc.subject.MESH | Risk Factors | - |
dc.title | A Comparison of Gastrointestinal Toxicities between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Pancreatic Cancer. | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Kyong Joo Lee | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.contributor.googleauthor | Jeong Youp Park | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Seung-woo Park | - |
dc.contributor.googleauthor | Jin Sil Seong | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.identifier.doi | 10.5009/gnl15186 | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A04777 | - |
dc.contributor.localId | A03602 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A01956 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 26470767 | - |
dc.subject.keyword | Chemoradiotherapy | - |
dc.subject.keyword | Endoscopy | - |
dc.subject.keyword | Gastrointestinal toxicities | - |
dc.subject.keyword | Pancreatic neoplasms | - |
dc.subject.keyword | Radiotherapy, intensity-modulated | - |
dc.contributor.alternativeName | Park, Seung Woo | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Yoon, Hong In | - |
dc.contributor.alternativeName | Chung, Moon Jae | - |
dc.contributor.alternativeName | Park, Jeong Youp | - |
dc.contributor.alternativeName | Bang, Seung Min | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Park, Seung Woo | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Yoon, Hong In | - |
dc.contributor.affiliatedAuthor | Chung, Moon Jae | - |
dc.contributor.affiliatedAuthor | Park, Jeong Youp | - |
dc.contributor.affiliatedAuthor | Bang, Seung Min | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 303 | - |
dc.citation.endPage | 309 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.10(2) : 303-309, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 45119 | - |
dc.type.rims | ART | - |
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