0 298

Cited 3 times in

A Retrospective Study of Methylprednisolone Mini-Pulse Therapy Combined with Narrow-Band UVB in Non-Segmental Vitiligo

Authors
 Jungsoo Lee  ;  Howard Chu  ;  Hemin Lee  ;  Miri Kim  ;  Dae Suk Kim  ;  Sang Ho Oh 
Citation
 DERMATOLOGY, Vol.232(2) : 224-229, 2016 
Journal Title
 DERMATOLOGY 
ISSN
 1018-8665 
Issue Date
2016
MeSH
Administration, Oral ; Adult ; Aged ; Anti-Inflammatory Agents/administration & dosage* ; Anti-Inflammatory Agents/adverse effects ; Combined Modality Therapy ; Female ; Humans ; Male ; Methylprednisolone/administration & dosage* ; Methylprednisolone/adverse effects ; Middle Aged ; Pulse Therapy, Drug ; Retrospective Studies ; Ultraviolet Therapy* ; Vitiligo/therapy* ; Young Adult
Keywords
Methylprednisolone ; Oral mini-pulse therapy ; Vitiligo, non-segmental
Abstract
BACKGROUND: Systemic corticosteroids have been used to arrest the progression of vitiligo. However, side effects have been a constant issue. OBJECTIVE: We evaluated the clinical efficacy and side effect of oral methylprednisolone (MPD) mini-pulse therapy combined with narrow-band UVB (NBUVB) for adults with non-segmental vitiligo retrospectively. METHODS: 32 patients with extensive and/or spreading vitiligo received 0.5 mg/kg MPD on 2 consecutive days per week with NBUVB therapy for at least 3 months. RESULTS: All of the 32 patients (100%) showed progression arrest within 12 weeks. Nineteen out of 32 patients (59.4%) presented repigmentation on more than 25% of lesions. Thirteen patients (40.6%) achieved satisfactory repigmentation in more than 50% of lesions. Only 2 patients discontinued the medication due to gastrointestinal trouble. CONCLUSION: Oral MPD mini-pulse therapy combined with NBUVB appears effective in arresting vitiligo progression and rapidly inducing repigmentation with minimal side effects.
Full Text
http://www.karger.com/Article/FullText/439563
DOI
10.1159/000439563
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Chu, Howard(곡원호)
Kim, Dae Suk(김대석)
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Jungsoo(이정수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146473
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse