377 246

Cited 10 times in

Retrospective Analysis on the Effects of House Dust Mite Specific Immunotherapy for More Than 3 Years in Atopic Dermatitis

DC FieldValueLanguage
dc.contributor.author박창욱-
dc.contributor.author이혜민-
dc.contributor.author신정우-
dc.contributor.author이광훈-
dc.contributor.author이정수-
dc.date.accessioned2017-02-24T07:33:56Z-
dc.date.available2017-02-24T07:33:56Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146455-
dc.description.abstractPURPOSE: In extrinsic atopic dermatitis (AD), house dust mites (HDM) play a role in eliciting or aggravating allergic lesions. The nature of skin inflammation in AD has raised a growing interest in allergen-specific immunotherapy (SIT). Thus, we assessed clinical improvement and laboratory parameters for evaluation of the benefit of long-term SIT. MATERIALS AND METHODS: A total of 217 AD patients who were treated with SIT for at least 3 years were retrospectively assessed, by using their investigator global assessment, pruritus scores, loss of sleep (LOS), total serum IgE, and eosinophil counts collected. Patients were additionally classified into subgroups according to age, initial AD severity and mono- or multi-sensitization to include different individual factors in the evaluation of SIT efficacy. Lastly, we compared laboratory data of good responders to SIT with that of poor responders to SIT. RESULTS: Improvement after SIT therapy was observed in 192 out of 217 patients (88.4%). Among these patients, 138 (63.5%) achieved excellent, near-complete or complete clinical remission. Significant reduction of pruritus, LOS, and the mean value of total serum IgE were observed (p<0.01). Better outcome was found in patients younger than 12 years of age (p=0.024). Patients with moderate to severe AD showed better treatment outcomes (p=0.036). Patients sensitized only to HDM had the better response to treatment, but SIT was also effective in multi-sensitized groups (p=1.051). No significant differences in baseline laboratory results were observed between good and poor responders (p>0.05). CONCLUSION: We emphasize the usefulness of long-term HDM SIT as a disease-modifying therapy for AD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent393~398-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAllergens/immunology*-
dc.subject.MESHAnimals-
dc.subject.MESHChild-
dc.subject.MESHDermatitis, Atopic/therapy*-
dc.subject.MESHDesensitization, Immunologic/methods*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPyroglyphidae/immunology*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleRetrospective Analysis on the Effects of House Dust Mite Specific Immunotherapy for More Than 3 Years in Atopic Dermatitis-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Dermatology-
dc.contributor.googleauthorJungsoo Lee-
dc.contributor.googleauthorHemin Lee-
dc.contributor.googleauthorSeongmin Noh-
dc.contributor.googleauthorByung Gi Bae-
dc.contributor.googleauthorJung U Shin-
dc.contributor.googleauthorChang Ook Park-
dc.contributor.googleauthorKwang Hoon Lee-
dc.identifier.doi10.3349/ymj.2016.57.2.393-
dc.contributor.localIdA01716-
dc.contributor.localIdA04650-
dc.contributor.localIdA02149-
dc.contributor.localIdA02674-
dc.contributor.localIdA04637-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid26847292-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordallergen-specific immunotherapy-
dc.subject.keywordhouse dust mites-
dc.contributor.alternativeNamePark, Chang Ook-
dc.contributor.alternativeNameLee, Hemin-
dc.contributor.alternativeNameShin, Jung U-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.contributor.alternativeNameLee, Jungsoo-
dc.contributor.affiliatedAuthorPark, Chang Ook-
dc.contributor.affiliatedAuthorLee, Hemin-
dc.contributor.affiliatedAuthorShin, Jung U-
dc.contributor.affiliatedAuthorLee, Kwang Hoon-
dc.contributor.affiliatedAuthorLee, Jungsoo-
dc.citation.volume57-
dc.citation.number2-
dc.citation.startPage393-
dc.citation.endPage398-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.57(2) : 393-398, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.