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Red cell volume distribution width-to-platelet ratio in assessment of liver fibrosis in patients with chronic hepatitis B
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.contributor.author | 김범경 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2017-02-24T03:44:02Z | - |
dc.date.available | 2017-02-24T03:44:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146426 | - |
dc.description.abstract | BACKGROUND & AIMS: Precise assessment of liver fibrosis is necessary in patients with chronic liver disease. We investigated the performance of red cell volume distribution width-to-platelet ratio for the assessment of liver fibrosis in patients with chronic hepatitis B. METHODS: A total of 482 consecutive patients with chronic hepatitis B who underwent liver biopsy between October 2005 and May 2014 were recruited. Liver stiffness was measured using transient elastography. FIB-4 score, red cell volume distribution width-to-platelet ratio and the aspartate aminotransferase-to-platelet ratio index were also assessed. RESULTS: A total of 271 (56.2%) patients were males. The median age was 44 years. F1, F2, F3 and F4 fibrosis stages were identified in 68 (14.1%), 137 (28.4%), 64 (13.3%) and 213 (44.2%) of the patients respectively. The mean red cell volume distribution width-to-platelet ratio increased with liver fibrosis severity: F1, 0.065; F2, 0.077; F3, 0.097 and F4, 0.121 (P < 0.01). The area under the receiver operating characteristic curve of the red cell volume distribution width-to-platelet ratio for predicting significant fibrosis (≥F2) was 0.747. This result was inferior to transient elastography (0.866, P = 0.004), but comparable to FIB-4 (0.782, P = 0.427) and aspartate aminotransferase-to-platelet ratio index (0.716, P = 0.507). The area under the receiver operating characteristic curve of red cell volume distribution width-to-platelet ratio for predicting cirrhosis (F4) was 0.811, which was inferior to liver stiffness (0.915, P < 0.001), but comparable to FIB-4 (0.804, P = 0.805) and superior to aspartate aminotransferase-to-platelet ratio index (0.680, P < 0.001). CONCLUSIONS: The accuracy of red cell volume distribution width-to-platelet ratio was acceptable for the assessment of liver fibrosis in patients with chronic hepatitis B. When transient elastography is not available, red cell volume distribution width-to-platelet ratio assessment is a simple method that can be used to reduce the need for liver biopsy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 24~30 | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Aspartate Aminotransferases/blood* | - |
dc.subject.MESH | Biopsy/methods | - |
dc.subject.MESH | Dimensional Measurement Accuracy | - |
dc.subject.MESH | Elasticity Imaging Techniques/methods | - |
dc.subject.MESH | Erythrocyte Indices* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B, Chronic/blood | - |
dc.subject.MESH | Hepatitis B, Chronic/complications | - |
dc.subject.MESH | Hepatitis B, Chronic/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver/pathology* | - |
dc.subject.MESH | Liver Cirrhosis*/blood | - |
dc.subject.MESH | Liver Cirrhosis*/diagnosis | - |
dc.subject.MESH | Liver Cirrhosis*/etiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Platelet Count/methods* | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.title | Red cell volume distribution width-to-platelet ratio in assessment of liver fibrosis in patients with chronic hepatitis B | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.contributor.googleauthor | Wonseok Kang | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Kwang Hyub Han | - |
dc.identifier.doi | 10.1111/liv.12868 | - |
dc.contributor.localId | A00385 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A03318 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 25966326 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/liv.12868/abstract | - |
dc.subject.keyword | chronic hepatitis B | - |
dc.subject.keyword | fibrosis | - |
dc.subject.keyword | liver stiffness measurement | - |
dc.subject.keyword | red cell volume distribution width-to-platelet ratio | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Lee, Hye Won | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 30 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.36(1) : 24-30, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 48414 | - |
dc.type.rims | ART | - |
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