Cited 13 times in
Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 김현기 | - |
dc.contributor.author | 정재호 | - |
dc.date.accessioned | 2017-02-24T03:40:00Z | - |
dc.date.available | 2017-02-24T03:40:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146410 | - |
dc.description.abstract | BACKGROUND: Aberrant TGF-β1 signaling is suggested to be involved in gastric carcinogenesis. However, the role of TGF-β1 in intestinal-type [i-GC] and diffuse-type [d-GC] gastric cancer remains largely unknown. In this study, we evaluated the expression of TGF-β1 signaling molecules and compared the clinicopathological features of i-GC and d-GC. METHODS: Patients (n=365, consecutive) who underwent curative gastrectomy for gastric adenocarcinoma in 2005 were enrolled. We performed immunohistochemical staining of TGF-β1, TGF-β1 receptor-2 (TβR2), Smad4, p-ERK1/2, TGF-activated kinase (TAK)1, and p-Akt in 68 paraffin-embedded tumor blocks (33 i-GC and 35 d-GC), scored the expression according to the extent of staining, and evaluated differences between the histologic subtypes. RESULTS: Patients with d-GC differed from those with i-GC as follows: younger and more likely to be female; more aggressive stage; higher recurrence rate. The expression of TGF-β1 and TβR2 was higher in i-GC (P = 0.05 and P <0.001, respectively). The expression of Smad4, a representative molecule of the Smad-dependent pathway, was decreased in both subtypes. TAK1 and p-Akt, two major molecules involved in the Smad-independent pathway, were over-expressed (69 ~87% of cases stained), without a statistically significant difference between i-GC and d-GC. Of note, the expression of p-ERK1/2, a Smad-independent pathway, was significantly increased in i-GC (P = 0.008). CONCLUSIONS: The clinicopathological characteristics vary in different histologic gastric cancer subtypes. Although TGF-β1 signaling in gastric cancer cells appears hyper-activated in i-GC compared to d-GC, the Smad-dependent pathway seems down-regulated while the Smad-independent pathway seems up-regulated in both histologic subtypes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 60 | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinogenesis/genetics* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intracellular Signaling Peptides and Proteins/biosynthesis | - |
dc.subject.MESH | Intracellular Signaling Peptides and Proteins/genetics | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitochondrial Proteins/biosynthesis | - |
dc.subject.MESH | Mitochondrial Proteins/genetics | - |
dc.subject.MESH | Neoplasm Proteins/biosynthesis* | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/surgery | - |
dc.subject.MESH | Transforming Growth Factor beta1/biosynthesis* | - |
dc.subject.MESH | Transforming Growth Factor beta1/genetics | - |
dc.title | Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Kyung Ho Pak | - |
dc.contributor.googleauthor | Dong Hoon Kim | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Do Hyung Lee | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.identifier.doi | 10.1186/s12885-016-2091-x | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A03717 | - |
dc.relation.journalcode | J00351 | - |
dc.identifier.eissn | 1471-2407 | - |
dc.relation.journalsince | 2001~ | - |
dc.identifier.pmid | 26846663 | - |
dc.subject.keyword | TGF-β1 | - |
dc.subject.keyword | Lauren classification | - |
dc.subject.keyword | Gastric cancer | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.citation.volume | 16 | - |
dc.citation.startPage | 60 | - |
dc.identifier.bibliographicCitation | BMC CANCER, Vol.16 : 60, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47918 | - |
dc.type.rims | ART | - |
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